摘要
以α D 葡萄糖为原料,经异丙叉基保护、异丙叉基选择性水解反应合成1,2 氧 异丙叉基 α D 葡萄糖。研究了影响异丙叉基选择性水解反应的主要因素,用核磁共振、红外光谱与薄层色谱等分析手段对水解产物进行了结构鉴定。两步反应总收率为45%。该合成方法简便,原料易得,具有较大的应用潜力。
The synthesis of 1,2-O-diisopropylidene-α-D-allofuranose was studied in this paper. With α-D-glucose as raw material, 1,2-O-isopropylidene-α-D-allofuranose was synthesized by isopropylidenation and selective hydrolyzation. The main factors that influence the hydrolysis reaction were studied. The final product was characterized by (~1H-NMR),IR,TLC and other method. The overall yield is 45%. The route is simple and convenient.The raw material can be obtained easily. This method has great potential for application.
出处
《化学工业与工程》
CAS
2005年第2期92-95,共4页
Chemical Industry and Engineering
基金
国家自然科学基金资助课题(项目编号20376059)
