新型多组分连续制备色谱系统——阵列式柱色谱

New Continuous Preparative Chromatography for Multi-Component Separation:Array Column Chromatography

本文介绍了一种新型多组分连续制备色谱系统———阵列式柱色谱。该系统是在综合了模拟移动床色谱和旋转环状色谱的工作原理的基础上开发出来的 ,主要由控制部分、流体输送部分、分离部分、检测部分和收集部分所组成。在分离部分中 ,本系统用色谱柱阵列代替了旋转环状色谱的环形填料层 ,即避免了溶质横向扩散和动密封问题 ,又可以根据实际生产需要增减色谱柱数目 ;在收集部分中 ,使用了专门为本系统设计的收集器实现了所有色谱柱流出液的集中收集 ;本系统采用将试验和生产一体化的设计 ,通过将单柱模式下的使用在线检测得出的优化分离条件应用到多柱模式中 ,实现了系统的柔性设计 ,降低了设备成本 ;用户可以通过使用装有系统控制软件的上位机与系统进行实时交互 ,大大提高了系统运行自动化程度 ,简化了操作。

Based on the theoretical foundation of simulated moving bed chromatography and annular chromatography,a new continuous preparative chromatography,array column chromatography,has been put forward in this paper.It comprises of four parts:control section,fluid transportation section,separation section and collection section.The spearation section is a chromatographic column array instead of annular bed in annular chromatography.The collection section is an exclusive collector which differs from general chromatography collectors.Both the fluid transportation section and the collection section are controlled by the control section.Multi-product can be prepared continuously in this system.Compared with other kinds of preparative chromatography,array column chromatography has a series of advantages,such as high flexibility,convenient operation,economical investment etc.