左旋氨氯地平治疗原发性高血压的动态血压观察

Efficacy of levamlodipine in treatment of hypertension by 24-hour ambulatory blood pressure monitoring

目的 利用动态血压监测技术观察左旋氨氯地平治疗原发性轻中度高血压降压疗效。方法 选取 4 0例轻中度高血压患者 ,试验前未服用降压药物或停用其他降压药物 1周以上 ,给予口服左旋氨氯地平 2 .5mg/d ,连续用药 4周。每周观察其诊所血压 ,如降压疗较差 ,加量至 5mg/d。所有患者于药物治疗前和治疗 4周后进行 2 4h动态血压监测。 结果 左旋氨氯地平能明显降低诊所血压 (P <0 .0 5 )。动态血压结果显示左旋氨氯地平有降低 2 4h血压 (P <0 .0 5 )。治疗前后的血压曲线呈分离状态。不良反应发生率为 5 %。结论 左旋氨氯地平作用于轻中度高血压病人可有效降低诊所血压和 2 4h血压 。

Objective To observe the efficacy of levamlopine on decreasing 24-hour blood pressure. Methods Forty patients with mild or moderate essential hypertension were given oral levamlodipine 2.5 mg once daily for 4 weeks. Ambulatory blood pressure monitoring(ABPM) was performed pre-and post-therapy. Results The clinical blood pressure of all patients were significantly lower after 4 weeks of therapy (P<0.05). Twenty-four h SBP and 24 h DBP decreased significantly (P<0.05). The blood pressure curve was separated. Adverse event incidence rate accounted for 5%. Conclusion Levamlodipine is an effctive angent with less side effects. Levamlodipine can decrease blood pressure during 24 hours.