牛磺酸与卡林-U滴眼液对实验性白内障大鼠治疗作用的比较

Comparison of the Therapeutic Effects between Taurine and Catalin Eye Drops on Experimental Cataract

目的 :比较牛磺酸与卡林 -U滴眼液治疗D -半乳糖致白内障模型大鼠的效果。方法 :将大鼠分为正常对照组、白内障对照组、牛磺酸组和卡林 -U组 ;除正常对照组外 ,各组均腹腔注射D -半乳糖进行白内障造模 ,之后给予相应药物点眼治疗 ,测量晶体中牛磺酸、甘氨酸、谷氨酸等氨基酸的含量。结果 :牛磺酸治疗组中的各种氨基酸的含量均不低于卡林 -U治疗组。结论 :牛磺酸眼水对实验性大鼠白内障具有一定的防治作用 ,甚至在某些方面比卡林 -U滴眼液更有优势。

OBJECTIVE:To compare the therapeutic effects of taurine and catalin eye drops.METHODS:All the mice were divided into the normal control group,the cataract control group,the taurine group and the catalin eye drops group.Except the normal control group,the rest ones were used to establish the galactose cataract models and then received eyedrop administration everyday.The contents of taurine,glycin and glutamic acid in crystalline lens were measured by high perforˉmance liquid chromatography.RESULTS:The contents of amino-acids were not found lower in the taurine group as comˉpared with the catalin eye drops group.CONCLUSION:Taurine shows the preventive and therapeutic effects on the experiˉmental cataract,which can be comparable to that of catalin eye drops or even more advantageous.