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抗乙肝新药阿德福韦酯的研究现状及展望 被引量:10

Review on the Study of New Drug Adefovir Dipivoxil for the Treatment of Hepatitis B
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出处 《中国药事》 CAS 2005年第3期169-171,共3页 Chinese Pharmaceutical Affairs
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  • 1Balzarini, J., Z. Hao, P. Herdewijn, et al . Intracellular metabolism and mechanism of antiretrovirus action of 9- (2-phosphonylmethoxyethyl ) adenine, a potent anti - human immunodeficiency virus compound [ J] . Proc. Natl. Acad. Sci.USA, 1991, 88:1499.
  • 2Seigneres, B., S. Aguesse- Germon, C. Pichoud, et al . Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo [J] . J. Hepatol. 2001, 34:114.
  • 3Barditch - Crovo P, Toole J, Hendrix CW, et al. Anti - human immunodeficiency virus activity and pharmacokinetics of adefovir depivoxil in HIV - infected patients [J] . J Infec Dis. 1997, 176(2): 406.
  • 4Nobel S, Goa KL. Adefovir dipivoxil [J] . Drugs, 1999.58:479.
  • 5Cullen JM, Li DH, Brown C, et al. Antiviral efficacy and pharmacokinetics of adefovir dipivoxol in chronically woodchuck hepatitis virus- infected woodchucks [ J ] .Antimicrob Agent Chemother. 2001, 45 (10): 2740.
  • 6Nicoll AJ, Colledge DL, Toole JJ, et al. Inhibition of duck hepatitis B virus replication by 9- (2- phosphonylmethoxyethyl) adenine,an acryclic phosphonate nucleoside analogue [ J] . Antimicrob Agent Chemother. 1998, 42:3130.
  • 7FDA Advisory Committee Briefing Document. Adefovir DipivoxilFor the Treatment of Chronic Hepatitis B. NDA 21 -449:77.
  • 8John M, Cullen, Daniel H. Li, et al. Antiviral Efficacy and Pharmacokinetics of Oral Adefovir Dipivoxil in Chronically Woodchuck Hepatitis Virus- Infected Woodchucks [ J ]Antimicrobial Agents and Chemotherapy, 2001, 45 (10): 2740.
  • 9Shaw JP, Louie MS, Krishnamurthy VV, et al. Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats [ J ] . Drug Metab Dispos, 1997, 25 (3): 362.
  • 10Gilson R J, Chopra KB, Newell AM, et al. A placebo- controlled phase Ⅰ/Ⅱstudy of adefovir dipivoxil in patients with chronic hepatitis B virus infection [J] . J Viral Hepat , 1999, 6:387.

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