炎症、动脉粥样硬化和心脑血管疾病

Inflammation,Atherosclerosis and Cardiovascular and Cerebrovascular Diseases

心脑血管疾病的病理基础是动脉粥样硬化,动脉粥样硬化被证实是细胞和分子的炎症反应。临床研究论证了炎症标记C 反应蛋白的增高预测心脑血管病发生的危险。C 反应蛋白已被美国心脏协会和疾病控制中心推荐为目前可信性最高的预测冠心病危险的临床检测指标,使极早期预测心脑血管疾病成为可能。至今发现的抗动脉炎症药物包括:阿司匹林、克皮格尔、他汀类降脂药和血管紧张素转换酶抑制剂。

Atherosclerosis is a major cause of cardiovascular disease and stroke.It has been demonstrated that atherosclerosis is an inflammatory disease involving a series of highly specific cellular and molecular responses.A number of clinical trials demonstrated that an elevated C-reactive protein level is associated with an increased risk of coronary and cerebrovascular events,independent of other known risk factors.American Heart Association and Centre for Disease Control addressed that it is reasonable to measure high sensitivity C-reactive protein as an adjunct to the major risk factors to further assess absolute risk for coronary disease primary prevention(class Ⅱa,level of evidence B).A group of pharmacotherapies including aspirin,clopidogrel,statins,angiotensin converting enzyme inhibitors have been shown,in addition to their other properties to reduce C-reactive protein and/or arterial inflammation.Antiinflammatory therapy may have clinical benefits,and then the goal of preventing cardiovascular and cerebrovascular diseases may be one step closer.