广西壮族自治区8月龄～4岁儿童麻疹抗体水平调查分析

Survey and Analysis of Measles Antibody Level Among Children in 8 Months to 4 Years in Gaungxi Zhuang Autonomous Region

目的 了解广西壮族自治区 8月龄～ 4岁儿童的麻疹抗体水平。方法 应用酶联免疫吸附试验 (ELISA)法对 981 8名 8月龄～ 4岁儿童进行麻疹抗体血清学调查。结果 麻疹抗体几何平均滴度 (GMT) 1∶1 0 0 4 ,阳性率82 8%,保护率 4 9 .4 %。 1 4个地区 (市 )、不同性别、年龄、接种史儿童的麻疹抗体阳性率、保护率差异均有显著的统计学意义 (P <0 .0 5 )。抗体阳性率 <80 %的县 (区 )占 3 7.4 %( 3 7/99) ,表明计划免疫工作发展不平衡 ,存在麻疹高危地区。结论 加强对这些地区甄别督查 ,在提高常规免疫覆盖率基础上 ,采取局部强化免疫 。

Objective In order to know the measles antibody level among children in 8 months to 4 years in Guangxi Zhuang Autonomous Region. Methods We carried out an investigation to 9818 children aged 8 months to 4 years old by ELISA method. Results The results showed that the measles antibody GMT was 1∶1004,positive rate was 82.8% and protective rate was 49.4%. The differences between measles antibody positive rate and protective rate among children in different gender, age, and immunization history were all statistically significant (p<0.05). The antibody positive rate was <80% in 37.4%(37/99) of the counties, which showed that the development of EPI in different areas was unbalanced and there were still some measles high-risk areas. Conclusion So in the future the main measures to prevent and control measles should be put on strengthening the identification and supervision to the high-risk areas, and conducting supplementary immunization in some areas on the basis of improving routine immunization coverage.