摘要
观察了由Ｆｅｎｔｏｎ反应产生的羟自由基（ＯＨ·）对人胚肺成纤维细胞的体外作用。结果表明，ＯＨ·能明显促进成纤维细胞增殖和胶原合成。由此推测，ＯＨ·可能对矽肺的发生起到一定作用。这个结论为矽肺的抗氧化防治提供了进一步理论依据。
The result indicated that hydroxyl radicals could enhance uptake of 3H-TdR and 3 H-Proline, proliferation and collagen synthesis of cultured HELF. Therefore, hydroxyl radicals may play a role in silicosis. The results indicate the possibility of prevention and therapy of silicosis by antioxidant and also help us to understand other fibrosis diseases.
出处
《卫生研究》
CAS
CSCD
北大核心
1994年第4期204-206,共3页
Journal of Hygiene Research
关键词
羟自由基
石英
矽肺
过氧化脂质
Hydroxyl radical
lipid peroxidation
fibroblast
silicosis
