化妆品对皮肤刺激试验的病理分析

Pathological analysis of irritation of cosmetic to skin

对２１０份化妆品皮肤刺激试验的病理诊断结果作了分析，病理反应积分为０者４９份，占２３．３３％，病理反应积分１～４者７５份，占３５．７１％，病理反应积分＞４者８６份，占４０．９５％；在收集到的８４０份皮肤标本中，有病理反应的５２０份，占６１．９０％，皮肤的反应以表皮和真皮同时出现改变较为多见，占５０．７７％，其次是单纯表皮反应，占３５．３８％，单纯真皮反应仅占１３．８５％；表皮反应以棘层肥厚最多见，真皮反应以真皮炎细胞浸润为主。

Pathological reaction of irritation of 210 cosmetic specimens to skin was analysed. The score of cumulative pathological reaction of 49 specimens is 0 (23. 33%), 75 specimens is 1～4 (35. 71%) and 84 specimens 1s > 4 (40. 95%). In the collected 840 skin samples, pathological reaction was detected in 520 samples (61. 90%). The changes observed simultaneously in epidermis and corium were the common forms of skin reactiOn, the change of epidermis and corium alone is respectively 35. 38% and 13. 85%. Acanthosis is the main pathological change of epidermis, accounting for 69. 20% of the total epidermis change. Secondly, hyperkeratosis, hypergranulosis and acanthosis were found simultaneously in epidermis, which account for 26.34% of epidermis change. Infiltration of inflammation cells is the common pathological change of corium (63. 69%). Infiltration and congestion account for 26. 19% of corium change. Institute of Environment Health Monitoring. Chinese Academy of Preventive Medicine