黄体生成激素释放激素刺激试验在闭经诊断上的意义

THE SIGNIFICANCANCE OF LH - RELEASING HORMONE STIMULATION TEST IN THE DIAGNOSIS OF PATIENTS WITH AMENORRHEA

对６例正常妇女及６０例闭经妇女作黄体生成激素释放激素（ＬＨＲＨ）刺激试验。结果：避孕药、针组中３例显示正常或高亢反应，４例无反应。下丘脑闭经组中，除１例精神性厌食无反应外，其余７例反应正常或高亢。垂体性闭经７例中，３例垂体瘤有反应，余４例无反应。对３２例闭经原因不明者进行试验后，发现其中２６例反应正常或高亢，提示闭经原因在下丘脑，６例无反应，可能属于垂体性闭经。５０μｇ与１００μｇ剂量的ＬＨＲＨ作刺激试验表明，二种剂量的结果无差异。提示：ＬＨＲＨ刺激试验在明确闭经的分类及选择ＬＨＲＨ脉冲治疗病例时是有价值的。

ix normal and sixty amenorrheic women underwent LHRH stimulation test.The results were as follows:In the group of contraceptive users,3 cases showed normal or high responses,and 4 had no response.In the group of hypothalamic amenorrheic patients,8 cases had normal or high responses besides one with anorexia nervosa.Among 7 cases of pituitary amenorrheic patients,3 cases with pituitary tumor responded to the LHRH stimulation test,and,4 cases had no response. Among 32 amenorrheic patients with unknown eiology,26 cases had normal or high responses to LHRH test.1t suggested that hypothalamus disturbance should be the underlying etiologic factors.6 patients who did not respond to LHRH might be caused by pituitary disorders.There were no significant differences between 50 μg and l00μgof LHRH used in the stimulation test.The result of this study suggested that the LHRH test be of value in the etiological classification of amenorrhea.The test could be used to screen the patients beforeLHRH pulsatile therapy.