血清可溶性细胞间粘附分子-1和E-选择素水平与冠心病的关系被引量：6

The correlation between the serum soluble ICAM-1 and E-Selectin and coronary heart disease

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摘要目的　比较冠心病(CHD)患者血清可溶性细胞间粘附分子- 1(sICAM -1)和血清可溶性E 选择素水平,探讨其临床意义。方法　145例冠心病患者,其中 73例为急性冠脉综合征组(ACS组), 72例为稳定型冠心病组 (SCHD组 ),并选 144名健康查体者作对照组。用酶联免疫吸附法(ELISA)检测血清sICAM -1、可溶性E 选择素水平,并比较上述指标水平在三组之间的差异。结果　血清sICAM -1浓度ACS组(320. 3±81. 8)μg/L和SCHD组(266. 5±63. 5)μg/L明显高于对照组(176. 3±78. 3)μg/L,P<0. 01,ACS组和SCHD组间也有显著性差异(P<0. 05)。血清可溶性E 选择素浓度ACS组(48. 5±12. 1)μg/L和SCHD组 (36. 1±11. 9)μg/L明显高于对照组(28. 8±10. 3)μg/L,P<0. 01,ACS组和SCHD组间也有显著性差异 (P<0. 05 )。结论　血清sICAM- 1、可溶性E 选择素在冠心病患者中明显高于对照组,其中ACS患者明显高于SCHD患者。 Objective To compare the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1) with soluble E-selectin (sE-selectin) and to discuss its role in coronary heart disease (CHD) patients.Methods We measured levels of serum sICAM-1 and sE-selectin among 145 CHD including 73 acute coronary syndrom (ACS) patients,72 stable coronary heart disease (SCHD) patients and 144 controls by enzyme-linked immunosorbent assay(ELISA).Results Serum sICAM-1 levels in group ACS (320.3±81.8)μg/L and in group SCHD (266.5±63.5)μg/L were significantly higher than those in controls(176.3±78.3)μg/L(P<0.01),whereas in group ACS is higher than those in group SCHD(P<0.05).Serum sE-selectin levels in group ACS (48.5±12.1)μg/L and in group SCHD (36.1 ±11.9)μg/Lwere significantly higher than those in controls (28.8±10.3)μg /L(P<0.01),whereas in group ACS is higher than those in group SCHD(P<0.05).Conclusion The levels of sICAM-1 and sE-selectin in CHD patients were significantly higher than controls and those in group ACS were significantly higher than in group SCHD.

作者饶丹姜红曾秋棠郭和平王敏李明慧

机构地区湖北省武汉市第八医院心内科上海复旦大学附属中山医院心内科华中科技大学同济医学院心血管病研究所

出处《临床内科杂志》 CAS 2005年第3期177-179,共3页 Journal of Clinical Internal Medicine

基金教育部留学人员回国基金资助项目教外司留[2002 ] 247

关键词冠心病血清可溶性细胞间粘附分子-1 血清可溶性E-选择素 Coronary heart disease sICAM-1 sE-selectin

分类号 R541.4 [医药卫生—心血管疾病]

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