幽门螺杆菌的清除与血液及胃液铋浓度关系

Relationship between eradication of Helicobacter Pylori and bismuth concentration in blood and gastric juice

对２０例幽门螺杆菌（ＨＰ）阳性患者，随机分为两组，分别以得乐冲剂（Ｄｅ－Ｎｏｌ，即胶态次枸橼酸铋，ＣＢＳ）和整肠生治疗３周，观察其ＨＰ的清除率。同时用氢化物原子荧光法测定治疗前后血液及胃液铋浓度并测定胃液ｐＨ值。结果：ＣＢＳ组ＨＰ清除率为５０％，治疗后血液及胃液铋浓度较治疗前均有显著升高（Ｐ＜０．０５），胃液ｐＨ值显著升高（Ｐ＜０．０１）。整肠生组ＨＰ清除率为２０％，治疗后血液铋浓度及胃液ｐＨ值较治疗前均无显著变化（Ｐ＞０．０５），但胃液铋浓度明显降低（Ｐ＜０．０５）。提示：胃液铋浓度是清除ＨＰ的关键，其最适浓度为５６μｇ／Ｌ。

Twenty patients with positive Helicobacter Pylori(HP) randomly classified into two groups were administered with colloidal Bismuth subcitrate (De-Nol) and Zheng Chang Sheng pills respectively for 3 weeks, and their eradication rates of HP were observed. Bismuth concentrations in blood and gastric juice were determined by atomic fluorescence method before and after treatment. The pH value of gastric juice was also registered. The results showed that in De-Nol group the eradication rates of HP was 50%, bismuth concentrations in both blood and gastric juice were increased after treatment (P<0. 05), and PH value of gastric juice was obviously elevated after treatment (P<0. 01). In Zheng Chang Sheng group, however, the HP eradieation rate was 20%, and the bismuth concentration in blood and pH value of gastric juice had no change after treatment (P>0. 05), but the bismuth concentration in gastric juice markedly decreased (P<0. 05). It is suggsted that bismuthh concentration in gastric juice is the key factor in HP eradication. and its suitable concentration for HP eradication is 56μg/L.