2-氨基-5-(4-吡啶基)-1,3,4-噻二唑Schiff碱的合成及其生物活性

Synthesis and Biological Activity of Schiff Bases of 2-Amino-5-(4-pyridyl)-1,3,4-Thiodiazol

含杂环的Schiff碱具有优良的生物活性,有的已被研究开发作为植物生长调节物质[1～4].1,3,4-噻二唑的某些衍生物也因为具有良好的杀菌、除草和植物生长调节等功能倍受关注[5～9].

Ten novel Schiff bases of 2-amino-5-(4-pyridyl)-1,3,4-thiodiazole have bee n synthesized in the yields of 46.9%~65.8%. The structures of the compounds we re confirmed by means of UV, IR, 1H NMR and elemental analysis. The pr eliminary room bioactivity tests showed that Schiff bases from chlorobenzaldehyd e and dichlorobenzaldehyde have a good plant growth regulation activity, where Ⅱc, Ⅱe and Ⅱg have excellent activities while auxin, Ⅱd and Ⅱi have better activities towards cytokinin.