云南省大理州人群发硒动态资料分析

Dynamic Analysis of Hair Selenium in Population in Dali Prefecture of Yunnan Province

目的探讨大理州克山病病区及非病区人群发硒动态变化、相互关系及其差异的显著性.方法对大理州11个克山病病区县市366份发样、5个病区县的88份粮食样及1个非病区30份发样进行了硒含量测定分析,并对2个重病区人群发硒进行了11年的连续监测分析.结果克山病病区农业人口发硒水平在0.112～0.186 mg/kg,平均为0.154 mg/kg,粮食硒含量平均在0.016 mg/kg;病区非农业户的人群发硒含量达到0.208 mg/kg,而非病区发硒水平在0.267 mg/kg;病区农业人口的发硒水平与非农业人口发硒水平之间有统计学差异(P＜0.01),病区农业人口与非病区人群之间发硒水平也有统计学差异(P＜0.01).结论人群发硒水平也有逐年上升趋势,与克山病发病率逐年下降呈正相关关系.硒预防克山病效果显著.

Objective To explore dynamic change of hair selenium level in population, relationship and significant difference among Keshan disease areas and non-Keshan disease areas. Methods The content of selenium was detected and analyzed in 366 sets of hair in 11 Keshan disease counties, 88 sets of cereals in 5 Keshan disease counties and 30 sets of hair samples in 1 non-Keshan disease county. And hair selenium was surveyed in 2 Keshan disease areas with high incidence for 11 years. Results The level of hair selenium was from 0.112 to 0.186 mg/kg (the average was 0.154mg/kg) and the average of selenium in cereals was 0.016 mg/kg in farm population. The average of hair selenium in non-farm population was 0.208mg/kg and the average of hair selenium in non-Keshan disease areas was 0.267mg/kg. Hair selenium was significantly different between farm population and non-farm population(P<0.01). Meanwhile, there were significant differences in the level of hair selenium among farm population and non-farm population, Keshan disease population and non-Keshan disease population(P<0.01). Conclusions There was increasing trend of hair selenium level as positively correlated with the incidence decreasing of Keshan disease annually. Selenium application for prevention Keshan disease has significant effect.