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SOX13与自身免疫糖尿病 被引量:1

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摘要 人类SOX13基因定位于染色体1q31.332.1,邻近1型糖尿病(T1DM)易感位点D1S504;其编码产物SOX13蛋白具有转录因子活性,可能调控内胚层细胞分化为胰腺以及胰岛素基因的表达。同时,研究发现T1DM自身抗原胰岛细胞抗体12是SOX13蛋白的同源物,由此提示SOX13基因或SOX13自身抗体与自身免疫糖尿病具有相关性。
出处 《国外医学(内分泌学分册)》 2005年第2期86-88,共3页 Foreign Medical Sciences(Section of Endocrinology)
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