期刊文献+

酮症倾向糖尿病 被引量:12

下载PDF
导出
摘要 酮症倾向糖尿病是一组临床综合征,主要包括1型糖尿病和酮症倾向的2型糖尿病。1型糖尿病发生酮症的原因主要为自身免疫所致胰岛素缺乏。酮症倾向的2型糖尿病可能有某些遗传缺陷,对葡萄糖毒性或糖脂毒性诱导的氧化应激敏感性增加,导致胰岛β细胞功能衰竭和胰岛素抵抗而发生酮症。1型糖尿病需胰岛素终身治疗,而酮症倾向的2型糖尿病在酮症纠正后且密切随访胰岛功能的情况下,可以使用口服降糖药治疗。
作者 张弛 周智广
出处 《国外医学(内分泌学分册)》 2005年第2期107-109,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 教育部跨世纪人才基金项目(200248) 湖南省卫生厅重点项目(A2004004) 吴阶平医学基金项目(2004)
  • 相关文献

参考文献10

  • 1Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care,2003,26(Suppl1): S5-S20.
  • 2Sobngwi E, Gautier JF. Adult-onset idiopathic type 1 or ketosis-prone type 2 diabetes: evidence to revisit diabetes classification. Diabetologia,2002,45 : 283-285.
  • 3Mauvais-Jarvis F, Sobngwi E, Porcher R, et al. Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history ofbeta-cell dysfunction and insulin resistance. Diabetes, 2004,53: 645-653.
  • 4Aguilera E, Casamitjana R, Oriola J,et al. Adult-onset atypical (type 1) diabetes:additional insights and differences with type 1A diabetes in a European Mediterranean population. Diabetes Care,2004,27:1108-1114.
  • 5Maldonado M, Hampe CS, Gaur LK, et al. Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and β-cell functional classification, prospective analysis, and clinical outcomes. J Clin Endocrinol Metab, 2003,88: 5090-5098.
  • 6Pinero-Pilona A, Litonjua P, Aviles-Santa L, et al. Idiopathic type 1 diabetes in Dallas, Texas: a 5-yesr experience. Diabetes Care, 2001,24:1014-1018.
  • 7Sobngwi E, Gautier JF, Riveline JP, et al. Ketosis-prone diabetes is associated to glucose-6-phosphate dehydrogenase deficiency in AfroCaribbean patients. Diabetes, 2003,52(Suppl1): A356.
  • 8Boutin P, Gresh L, Cisse A, et al. Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children. Diabetologia, 1999,42: 380-381.
  • 9Mauvais-Jarvis F, Boudou P, Sobngwi E, et al. The polymorphism Gly574Ser in the transcription factor HNF-1alpha is not a marker of adult-onset ketosis-prone atypical diabetes in Afro-Caribbean patients.Diabetologia, 2003,46: 728-729.
  • 10Mauvais-Jarvis F, Smith SB, May CL, et al. PAX4 gene variations predispose to ketosis-prone diabetes. Hum Mol Genet, 2004,13:3151-3159.

同被引文献64

  • 1朱鋐达,陈名道.酮症起病的糖尿病[J].中华内分泌代谢杂志,2004,20(4):378-380. 被引量:26
  • 2张弛,周智广,张冬梅,杨晓琳,周敏,林健,黄干,王建平.急骤起病伴胰酶增高的1型糖尿病临床和免疫学特征[J].中华医学杂志,2005,85(14):967-971. 被引量:46
  • 3金文胜,潘长玉.国际糖尿病联盟关于代谢综合征定义的全球共识[J].中华内分泌代谢杂志,2005,21(4):412-413. 被引量:157
  • 4王霁云,张丽华,尹建梅,王红.56例自发酮症初发糖尿病患者的临床分析[J].中国慢性病预防与控制,2006,14(3):185-186. 被引量:3
  • 5Maldonado M,Hampe CS,Gaur LK, et al. Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunoge netic and 13-cell function classification, prospective analysis, and clinical outcomes. J Clin Endocrinol Metab, 2003,88 : 5090-5098.
  • 6Kobayashi T, Nakanishi K, Murase T,et al. Small doses of subcutaneous insulin as a strategy for preventing slowly progressiveβ- cell failure in islet cell antibody-positive patients with clinical features of NIDDM. Diabetes, 1996,45 : 622.
  • 7Myers MA, Rabin DU,Rowley MJ. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic decarboxylase. Diabetes, 1995, 44: 1290-1295.
  • 8Mauvais JF, Sobngwi E, Porcher R, et al. Ketosis-prnne type2 diabetes in patients of Sub-Saharan origin : clinical pathophysiology and nayural history of beta-cell dysfunction and insulin resistance [ J ]. Diabetes ,2004,53 ( 11 ) :645-653.
  • 9Maldonado M, Hampe CS, Gaur LK, et at. Ketosis-prone diabetes; dissection of a heterogeneous syndrome using an immunogentic and B-cell functional lassification, prospective analysis, and clinical outcomes[J]. J Clin Endocrinol Metab,2002,88(3):5090-5098.
  • 10Umpierrez GE. Ketosis - prone Type 2 Diabetes : Time to revise the classification of diabetes[ J]. Diabetes care ,2006,29:2755 - 2757.

引证文献12

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部