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涉及11q23/MLL重排的急性白血病 被引量：1

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摘要 大约5%～10%的人类白血病包括初发和治疗相关性白血病伴有11q23/MLL重排.白血病伴有11q23/MLL重排提示预后不良.位于11q23的MLL基因与各种不同的伙伴基因发生嵌合,产生独特的具有新的功能的融合蛋白.目前已发现的MLL伙伴基因达30余种.又有一些新的MLL融合伙伴基因被确定.某些携带11q23/MLL重排的细胞株已经被用来作为模型系统,探索MLL基因及它们的伙伴基因在致癌过程中的表达及功能的改变.白血病预后不良与11q23/MLL重排有关.Allo-SCT对伴有11q23/MLL重排的白血病的疗效有限.针对11q23/MLL重排的特异性治疗将给这类白血病患者带来希望.
作者 胡晓梅 麻柔
机构地区 中国中医研究院西苑医院血液科
出处 《白血病．淋巴瘤》 CAS 2005年第1期52-56,共5页 Journal of Leukemia & Lymphoma
关键词 染色体 11q23/MLL重排 急性白血病
分类号 R733.71 [医药卫生—肿瘤]
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参考文献39

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同被引文献17

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  • 2王光海,江涛.MRP1与肺癌耐药[J].临床肺科杂志,2005,10(3):367-368. 被引量：7
  • 3柯爱武,李羲.脂质体逆转肿瘤多药耐药研究进展[J].国外医学（预防．诊断．治疗用生物制品分册）,2005,28(2):75-80. 被引量：6
  • 4陈为民,廖丽升,林芸,陈碧云,宋团月,李丽英.急性单核细胞白血病8年诊治回顾(附68例报告)[J].福建医药杂志,2005,27(5):8-10. 被引量：11
  • 5左明新,叶爱军,胡欣.多药耐药性相关ATP结合盒转运蛋白[J].国外医学（药学分册）,2005,32(6):365-368. 被引量：5
  • 6龚玉萍 贾永前 刘霆 等.环孢霉素A和Genistein逆转多药耐药的实验研究.癌症,2004,21(5):544-546.
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  • 8Benderra Z,Faussat A,Sayada L,et aI.MRP3,BCRP and P-Glycoprotein activities are prognostic factors in adult acute myeloid leukemia[J]. Clin Cancer Res, 2005,11 (21 ) : 7764- 7772.
  • 9Marzac C,Teyssandier I, Calendini O, et al.Fh3 internal tandem duplication and P-glycoprotin functionality in 171 patients with acute myeloid leukemia[J]. Clin Cancer Res, 2006,12(23 ) : 7018-7024.
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白血病．淋巴瘤
2005年 第1期

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