慢性重型肝炎患者低氧血症31例动态观察

Dynamic observation on 31 anoxemic cases of chronic severe hepatitis

目的 探讨慢性重型肝炎患者动脉血氧分压 (PaO2 )的变化与病情的关系。方法 用血气分析检测 31例慢性重型肝炎患者PaO2 的动态变化 ,并比较生存患者和死亡患者的PaO2 变化。结果 慢性重型肝炎患者PaO2 变化与凝血酶原活动度 (PTA)的变化相一致。生存患者PaO2 在达到一个最低值后随着PTA的增高而增高 ;死亡患者的PaO2 则进行性降低 ,在死亡前达极低值。生存患者与死亡患者PaO2 、总胆红素 (TBil)、PTA比较差异均有统计学意义。结论 慢性重型肝炎患者PaO2 明显降低 ,而且与PTA的变化有相关性 ,动态观察慢性重型肝炎患者PaO2 的变化可作为判断病情的指标之一。

Objective To study the relationship between the PaO 2 changes of chronic severe hepatitis and the development of disease.Methods Using blood gas analysis to detect the PaO 2 dynamic variety of 31 cases of chronic severe hepatitis.The PaO 2 of survival cases and dead cases were compared.Results The varieties of PaO 2 of chronic severe hepatitis cases were consistent with the varieties of prothrombin activity (PTA).After the PaO 2 of survival cases arrived at lowest degree,the degree of PaO 2 increased with the increase of PTA.But the PaO 2 of dead cases was consecutively decreasing and arrived at the lowest degree before dying.There was significant variability in PaO 2,Tbil and PTA between the survival cases and the dead cases.Conclusion The PaO 2 of chronic severe hepatitis showed a marked decrease,correlating with the varietyof PTA.Dynamic observation of PaO 2 can be one of the indicators on disease development.