北五味子的镇静、催眠作用

Preliminary study on the sedative and hypnotic effects of the water extract of Fructus schisandrae Chinensis

目的对北五味子水提取物镇静、催眠药理作用进行初探。方法采用镇静、催眠实验观察北五味子水提取物对小鼠自主活动的影响 ,协同戊巴比妥钠对小鼠的催眠作用。结果北五味子水提取物能明显减少小鼠自主活动次数 ,增加阈下剂量戊巴比妥钠致小鼠睡眠只数 ,延长阈上剂量戊巴比妥钠致小鼠睡眠时间。结论北五味子水提取物有明显的镇静、催眠作用。

Objective To make a preliminary study on the sedative and hypnotic effects of the water extract of Fructus schisandrae Chinensis.Method Sedative and hypnotic experiments were made to observe the effects of the water extract of Fructus schisandrea Chinensis on spontaneous motion and hyponosis in mice.Results The results showed that the water extract of Fructus schisandrae Chinensis could markedly inhibit spontaneous motion,enhance the sleeping number of pentobarbital sodium (subthreshold dosage) and prolong the sleeping time of pentobarbital sodium (superthreshold dosage).Conclusion The water extract of Fructus schisandrae Chinensis possesses obvious sedative and hypnotic effects.