摘要
PTCH基因是Shh/PTCH/Smo信号转导通路中重要的调节因子,近来研究表明PTCH基因的突变与人牙源性囊肿的发生密切相关。本文将PTCH的分子结构、信号转导及与肿瘤和牙源性囊肿发生的关系作一综述。
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