血栓素A_2、前列环素对重症急性胰腺炎并发肾损害的影响

THE INFLUENCE OF TXA_2、PGI_2 IN EXPERIMENTAL SEVERE ACUTE PANCREATITIS WITH KIDNEY DAMAGE

目的 探讨血栓素 A2 (thromboxane A2,TXA2)、前列环素(prostacyclin,PGI2)在重症急性胰腺炎并发肾损害中的作用。方法 采用 5 % 牛磺胆酸钠多点位胰腺被膜下注射建立重症急性胰腺炎模型,观察炎性介质TXA2、PGI2、血淀粉酶的变化、肾功能改变及奥扎格雷钠(TXA2 合成酶抑制剂)的治疗作用。结果 重症急性胰腺炎时TXA2、PGI2 的明显改变与肾损害的严重程度密切相关。奥扎格雷钠可减轻肾脏损害程度。结论 TXA2、PGI2 介导了重症急性胰腺炎并发肾损害,奥扎格雷钠对重症急性胰腺炎并发肾损害有治疗价值。

ObjectiveTo study the role of thromboxane A_2(TXA_2)、prostacyclin(PGI_2) in experimental severe acute pancreatitis(SAP) with kidney damage. MethodsThe roles of inflammatory mediators(TXA_2、PGI_2) were investigated in SAP model established by injection of (5 %) sodium taurocholate((0.15) mL/100g) under pancreatic capsule and the therapeutic efficiency of ozagrel on SAP was observed. ResultsSAP could induce obvious change of TXA2、PGI_2 which was positively correlated with the damage of kidney and pancreas. Ozagrel could inhibit the production of TXA_2 and alleviate damage of pancreas and kidney. ConclusionTXA_2、PGI_2 play an essential role in SAP and the kidney damage, ozagrel may be the efficient treatment to prevent the development of SAP and kidney damage.