摘要
目的: 探讨辛伐他汀对急性冠脉综合征(ACS)患者血清肿瘤坏死因子- α(TNF -α)及一氧化氮(NO)含量变化的影响。方法: 采用双盲法将55例急性冠状动脉综合征患者随机分为辛伐他汀组(n=27例)和常规治疗组(n=28例),分别于治疗前及治疗后3周行血清TNF- α及NO检测。结果:①辛伐他汀组治疗后与治疗前比较,血清TNF α明显降低,NO显著升高(P<0 .01);②常规组治疗前后,血清TNF- α、NO变化不明显(P>0 .05)。结论: 辛伐他汀可降低急性冠脉综合征患者血TNF- α水平,升高NO水平,具有稳定粥样斑块和保护血管内皮的作用。
Objective:To investigate the effect of simvastatin on changes in serum concentrations of NO and tumor necrosis factor-α (TNF-α ) in patients with acute coronary syndromes (ACS). Methods:55 patients with ACS were randomly divided into simvastatin group (n=27) and routi ne therapy group (n=28).Serum TNF-α and NO levels were measured before and thr ee weeks after the two treatment options respectively.Results: ①The level of TNF-α was decreased significantly and NO content got increased markedly after simvastatin therapy(P<0.01).②The concentrations of TNF- α and NO changed only slightly after the routine therapy(P>0.05).C onclusions:Simvastatin could reduce the levels of TNF-α and increase NO concentration in patients with ACS,stabilizing atherosclerotic plaque and pro tecting the endothelial function.
出处
《临床误诊误治》
2005年第3期153-155,共3页
Clinical Misdiagnosis & Mistherapy
关键词
辛伐他汀
冠脉综合征
肿瘤坏死因子
一氧化氮
治疗
Simvastatin
Acute coronary syndromes
Tumor necrosis factor-α
Nitric oxide
Therapy