辛伐他汀对急性冠脉综合征患者肿瘤坏死因子及一氧化氮含量的影响

Effect of Simvastatin on Concentration of TNF-α and NO in Patients wit h Acute Coronary Syndromes

目的: 探讨辛伐他汀对急性冠脉综合征(ACS)患者血清肿瘤坏死因子- α(TNF -α)及一氧化氮(NO)含量变化的影响。方法: 采用双盲法将55例急性冠状动脉综合征患者随机分为辛伐他汀组(n=27例)和常规治疗组(n=28例),分别于治疗前及治疗后3周行血清TNF- α及NO检测。结果:①辛伐他汀组治疗后与治疗前比较,血清TNF α明显降低,NO显著升高(P<0 .01);②常规组治疗前后,血清TNF- α、NO变化不明显(P>0 .05)。结论: 辛伐他汀可降低急性冠脉综合征患者血TNF- α水平,升高NO水平,具有稳定粥样斑块和保护血管内皮的作用。

Objective:To investigate the effect of simvastatin on changes in serum concentrations of NO and tumor necrosis factor-α (TNF-α ) in patients with acute coronary syndromes (ACS). Methods:55 patients with ACS were randomly divided into simvastatin group (n=27) and routi ne therapy group (n=28).Serum TNF-α and NO levels were measured before and thr ee weeks after the two treatment options respectively.Results: ①The level of TNF-α was decreased significantly and NO content got increased markedly after simvastatin therapy(P<0.01).②The concentrations of TNF- α and NO changed only slightly after the routine therapy(P>0.05).C onclusions:Simvastatin could reduce the levels of TNF-α and increase NO concentration in patients with ACS,stabilizing atherosclerotic plaque and pro tecting the endothelial function.