塑料电泳芯片热键合的试验研究

EXPERIMENTAL STUDY ON THERMAL BONDING FORPLASTIC CAPILLARY ELECTROPHORESIS CHIPS

塑料电泳芯片具有绝缘性、透光性好、价格便宜、成型容易和批量生产成本低等优点,是一种新型微型分析装置。研究塑料电泳芯片热键合工艺过程和工艺参数,通过试验建立微通道变形与热键合温度、压力、时间和模压工艺参数的关系,由此提出减小微通道变形的方法,对于完善塑料电泳芯片结构设计和制作的基本理论和基本技术具有积极意义。

A plastic capillary electrophoresis chip is a novel kind of miniaturized device for biochemistry analysis. The major advantages of the chip include high transmittance for light; low conductivity for electrokinetic pumping and electro phoretic separation; low cost for high volume production and disposal and easily manufacturing for high aspect ratio of microchannels on the chip. A process of thermal bonding for plastic capillary electrophoresis chips is studied, the relationships between the changes of the dimensions of the microchannels and the process conditions of thermal bonding and hot embossing, including temperature, pressure and time are established by experiment, based on these the ways to reduce the changes are proposed, which lays the foundation for basic theories and techniques of structural design and manufactures of the plastic chip.