急性低温低氧复合环境对心肌缺血家兔脂质过氧化的影响

Effects of Acute Low Temperature and Hypoxia on Serum SOD Activity and MDA Content of Myocardial Ischemia Rabbit

目的探讨心肌缺血的家兔在急性低温低氧复合环境下血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量的变化。方法将24只家兔随机分成3组:正常低温低氧组,心肌缺血常温常氧组和心肌缺血缺氧组。将心肌缺血的家兔置于低温(-10±2)℃和低氧(氧含量为8.5%)冷柜中1h,然后取动脉血测定血清中SOD活力和MDA含量。结果心肌缺血的家兔在急性低温低氧环境中血清中的SOD活力比在常温常氧下显著降低(P<0.01),MDA含量明显升高(P<0.05)。心肌缺血的家兔在急性低温低氧环境中血清SOD活力、MDA含量与正常家兔在急性低温低氧环境中相比,均无明显变化。结论急性低温复合低氧对心肌缺血的家兔有加重心肌缺血作用。

Objective To study the effects of acute low temperature and hypoxia on serum SOD and MDA of myocardial ischemia rabbit. Methods 24 rabbits were randomly divided into 3 groups, such as normally low tamperature and hypoxia group, myocardial ischemia normal temporature and normal oxygen group and myocardial ischemia low temporature and hypoxia group. Put myocardial ischemia rabbits into the condition in which low temperature(-10±2) ℃ and hypoxia (oxygen content 8.5% ) existed, superoxide dismutase (SOD) activity and malondialdehyde (MDA) contents were measured after an hour. Results Serum SOD activity were decreased significantly in acute low temperature and hypoxia compared with normal temperature and normal oxygen pressure (P<0.01). Under the same experimental conditions, the MDA contents were increased significantly (P<0.05). Conclusion Acute low temperature and hypoxia may make damages of myocardial ischemia rabbits much severe.