摘要
目的 :观察罗格列酮对 2型糖尿病高脂血症的影响。方法 :口服罗格列酮 4mg ,bid。结果 :与治疗前相比 ,空腹血糖 (FPG)、餐后 2h血糖 (2hPG)、糖化血红蛋白 (HbA1c)、甘油三酯 (TG)及总胆固醇 (TC)均有不同程度的下降 ,高密度脂蛋白胆固醇 (HDL -C)增高。结论 :罗格列酮抑制周围组织脂肪的分解 ,减少游离脂肪酸(FFA)释放 ,使肝VLDL及TG生成减少 ,同时增加脂蛋白脂酶 (LPL)活性 ,使周围组织降解增加 ,血脂降低。
Objective:To observe the effect of rosiglitazone on type 2 diabetes with hyperlipemia. Methods:Rosiglitazone was taken orally in a dose of 4mg, two times a day.Results:After treatment, the levels of FPG,2hPG ,HbA1 C,TG and TC all decreased to varyng degrees descent, the level of high density lipoprotein(HDL-C)increased. Conclusion: Rosiglitazone can inhibit decomposition of surrounding fatty tissue and reduce release of FFA,thus the production of VLDL and TG is reduced in liver,the activity of the LPL is improved, degradation of VLDL and TG is quickened and the level of blood lipid is depressed simultaneously.
出处
《医学理论与实践》
2005年第3期256-257,共2页
The Journal of Medical Theory and Practice
