期刊文献+

缺血心肌的血管新生——从分子基础到临床应用

下载PDF
导出
摘要 缺血性心脏病严重危害着人类健康。而治疗性血管新生为这类疾病的攻克带来了新的希望,因此越来越受到人们关注,成为研究的热点之一。本文由其分子基础,谈到临床应用,综述了血管生成的过程与机制,促进血管新生的主要因子,以及治疗性血管新生的理论基础与主要策略,进而结合有关研究成果,对治疗性血管新生临床应用中面临的问题和前景等方面略作探讨。
出处 《生理通讯》 2005年第1期7-11,共5页
  • 相关文献

参考文献17

  • 1Richard DE, Berra E, gur JP. Angiogenesis: how a tumor adapts to hypoxia. Biochem Biophys Res Commun, 1999(266): 718-722.
  • 2Schaper W, Buschmann I. VEGF and therapeutic opportunities in cardiovascular diseases. Curr Opin Biotechnol, 1999(10) : 541-543.
  • 3Post M J, Laham R, Sellke FW, et al. Therapeutic angiogenesis in cardiology using protein formulations.Cardiovasc Res, 2001(49) : 522-531.
  • 4Mehrabi MR, Serbecic N, Tamaddon F, et al. Clinical benefit of Prostaglandin El-treatment of patients with ischemic heart disease: stimulation of therapeutic angiogenesis in vital and infarcted myocardium.Biomed Pharmacother, 2003(57) : 173-178.
  • 5Mehrabi MR, Ekmekcioglu C, Stanek B, et al. Angiogenesis Stimulation in Explanted Hearts from Patients Pre-Treated with Intravenous Prostaglandin El.J Heart Lung Transplant, 2001(20) : 465-473.
  • 6Mehrabi MR, Serbecic N, Tamaddon F, et al. Clinical and experimental evidence of prostaglandin El-induced angiogenesis in the myocardium of patients with ischemic heart disease. Cardiovasc Res, 2002 (56) :214-224.
  • 7Rubanyi GM, Johns A, Kauser K. Effect of estrogen on endothelial function and angiogenesis. Vascul Pharmacol, 2002(38): 89-98.
  • 8Rasmussen HS, Rasmussen CS, Macko J. VEGF gene therapy for coronary artery disease and peripheral vascular disease. Cardiovasc Radiat Med, 2002(3): 114-117.
  • 9Khurana R, Simons M. Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease. Trends Cardiovasc Med, 2003(13): 116-122.
  • 10Oyama K, Ohnuki T , Ohnuki N , et al. The effect of basic fibroblast growth factor (bFGF) on early bronchial revascularization. Nippon Kyobu Geka Gakkai Zasshi, 1996 ,44(11) :2032-2039.

二级参考文献11

  • 1Willersor JT, Cohn JN. Cardiovascular Medicine. 2nd, [ M ],Churchill Livingstone ,2000 : 1417-14254.
  • 2Folkman J. From the lab to the clinic: one investigator's journey [J]. J Law Medicine & Ethics,2002,30(3) :361-366.
  • 3Welsh LC. Vascular growth factors and angiogenesis[ M]. Berlia:Springer, 1999 : 138,165.
  • 4Ghosh PK, Vasanji A, Murugesan G,et al. Membrane microviscosity regulates endothelial cell mobility [ J ]. Nat Cell Biol, 2002,4( 11 ) :894-900.
  • 5Hauck CR, Klingbeil CK, ,Schaepfer DD. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration [ J ]. Immunol Res, 2000,21 ( 2-3 ) : 293-303.
  • 6Oyama K, Ohnuki T, Ohnuki N ,et al. The effect of basic fibroblast growth factor (bFGF) on early bronchial revascularization[ J]. Nippon Kyobu Gekka Zasshi, 1996,44 (1) :2032-2039.
  • 7Thurston G, Rudge JS,Loffe E,et al. Angiopoietin-1 protects the adult vasculature against plasma leakage [ J ]. Nat Med 2000, 6(4). :460-463.
  • 8Jung YD, Mansfield PF,Akagi M,et al. Effects of combination anti-vascular endothelial growth factor receptor and antl-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model[J]. Eur J Cancer, 2002,38(8) :1133-1140.
  • 9Asara T, Murohara T, Sullivan A,et al. Isolation of putative progenitor endothelial cells for angiogenesis [ J ]. Science, 997,275(14) :964-967.
  • 10Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function and cardiovascular risk [ J ]. N Eng J Med ,2003.348(7 ) :593-600.

共引文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部