期刊文献+

prostasin与前列腺癌研究新进展

下载PDF
导出
摘要 前列腺癌是泌尿系统肿瘤最常见的肿瘤之一 ,其发病率和死亡率有增长趋势。因此 ,寻找一种特异的诊断指标以早期发现前列腺癌显得尤其重要。prostasin是于 1994年在人类精液中发现的一种丝氨酸蛋白酶[1 ] 。近年来的研究表明其在前列腺组织中的表达或缺失与前列腺癌的发生发展有密切的关系。
机构地区 [
出处 《国外医学(泌尿系统分册)》 2005年第2期153-155,共3页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
  • 相关文献

参考文献19

  • 1Yu JX, Chao L, Chao J. Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. J Biol Chem, 1994,269(29): 18843 - 8.
  • 2Yu JX, Chan L, Chao J.Structure and chromosomal localization of the human prostasin(PRSS8) gene. Genomics,1996,32(3) :334- 40.
  • 3Yu JX, Chao L, Chan J. Molecular cloning, tissue - specific expression,and cellular localization of human prostasin mRNA. J Biol Chem, 1995,270(22): 13483 - 9.
  • 4Chen LM, Skinner ML, Kauffman SW, et al. Prostasin is a glycosylphosphatidylinositol- anchored active serine protease. J Biol Chem,2001,276(24) :21434 - 42.
  • 5Wang C, Chao J, Chan L. Adenovirus - mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats. Am J Physiol Regul Integr Comp Physiol, 2003,284(4): R1031 - 6.
  • 6Vuagnianx G, et al. Activation of the amiloride - sensitive epithelial sodium channel by the serione protease mCAP1 expressed in a mouse cortical collecting duct cell line. J Am Soc Nephrol,2000,11:828- 34.
  • 7Donal dson SH,Hirsh A,Li DC.Regulation of the epithelial sodium channel by serine proteases in human airways. J Biol Chem,2002,277(10):8338 - 45.
  • 8Iwashita K, Kitamura K, Narikiyo T, et al. Inhibition of prostasin secretion by serine protease inhibitors in the kidney. J Am Soc Nephrol,2003, 14(1):11-6.
  • 9Adachi M, Kitamura K, Miyoshi T, et al. Activation of epithelial sodium channels by prostasin in Xenopus oocytes. J Am Soc Nephrol, 2001, 12(6): 1114 - 21.
  • 10Adachi M,et al. Activation of epithelial sodium channels by expression,and cellular localization of human prostasin mRNA.J Biol Chem,2001,270:13483 - 13489.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部