期刊文献+

瘦素与骨代谢

下载PDF
导出
摘要 瘦素是与饱食和能量平衡有关的激素 ,被认为是抗肥胖因子。瘦素同样对诸如性发育、生殖、造血、免疫、胃肠道功能、交感神经活性及血管形成多方面有调节作用。针对瘦素与骨的关系问题过去研究较少 ,近年来已报道很多研究工作。本文主要综述瘦素对骨骼系统的外周刺激作用和中枢抑制作用以及在慢性肾衰患者中 。
出处 《国外医学(泌尿系统分册)》 2005年第2期260-262,共3页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
关键词 骨和骨细胞
  • 相关文献

参考文献20

  • 1Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature, 1994,372(6505) :425 - 32.
  • 2Considine R V, Sinha MK, Heiman ML, et al. Serum immunoreactive- leptin concentrations in normal - weight and obese humans. N Engl J Med,1996,334(5) :292 - 5.
  • 3Whipple T, Sharkey N, Demers L, et al. Leptin and the skeleton. Clin Endocrinol,2002,57(6) :701 - 11.
  • 4Tremollieres FA, Pouilles JM, Ribot C. Vertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 early postmenopausal women. J Clin Endocrinol Metab, 1993,77(3) :683- 6.
  • 5Thomas T, Gori F, Khosla S, et al. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology, 1999,140(4): 1630 - 8.
  • 6Holloway WR, Collier FM, Aitken CJ, et al. Leptin inhibits osteoclast generation. J Bone Miner Res,2002,17(2) :200 - 9.
  • 7Reseland JE, Syversen U, Bakke Ⅰ, et al. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res,2601,16(8): 1426 - 33.
  • 8Steppan CM, Crawford DT, Chidsey - Frink KL, et al. Leptin is a potent stimulator of bone growth in ob/ob mice. Regul Pept,2000,92( 1 - 3) :73-8.
  • 9Ducy P, Amling M, Takeda S, et al. Leptin inhibits bone formation through a hypothalamic relay:a central control of bone mass. Cell,2000,100(2):197-207.
  • 10Caro JF, Kolaczynski JW, Nyee MR, et al. Decreased cerebrospinal- fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet, 1996,348(9021 ): 159 - 61.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部