幽门螺杆菌对肝硬化患者胃粘膜病变致病作用的观察

Observation of pathopoiesis of Helicobacter pylori in gastric mucosal lesion of patients with liver cirrhosis

目的 探讨幽门螺杆菌(Hp)感染在肝硬化(L C)患者胃粘膜病变中的意义。方法 接受内镜检查的L C患者2 0 4例,非L C患者2 36例。快速尿素酶试验,Warthin- Starry染色诊断Hp感染。结果 L C合并门脉高压性胃病和肝源性溃疡患者的胃粘膜Hp感染率分别为30 .6 9%和4 2 .4 2 % ,与L C无胃粘膜病变者(36 .14 % )相比无明显差异(P>0 .0 5 ) ;L C患者Hp感染率(34.31% )低于非L C患者(48.31% ,P<0 .0 1)。结论 Hp感染不是肝硬化患者胃粘膜病变的主要致病因素。

Objective To probe the role of Helicobacter pylori(Hp)infection in gastric mucosal lesion in patients with liver cirrhosis(LC).Methods Gastroscopy was performed in 204 LC patients and 236 no-LC patients.Hp infection was verified by rapid urease test and Warthin-Starry silver stainning.Results The Hp infection rate in LC patients with portal hypertensive gastropath(PHG)and with hepatogenic ulcer(HPU)was 30.69% and 42.42%,respectively,no significant difference was found between patients with gastric mucosal lesion and without gastric mucosal lesion(P>0.05).The Hp infection rate in LC patients(34.31%) was significantly less than that in no-LC patients (48.31,P<0.01).Conclusion Hp infection might not be the main etiological factor for gastric mucosal lesion seen in LC patient.