磷霉素钠治疗新生儿呼吸道感染219例

Observations on the therapeutic effect of sodium fosfomycin in 219 newborns with respiratory tract infection

目的 观察磷霉素钠治疗新生儿呼吸道感染(RTI)的疗效及副作用。方法 观察组2 19例给予磷霉素钠每日10 0～30 0 mg·kg- 1 ,加入2 5 0 m l生理盐水分2次静脉滴注;对照组给予青霉素G每日2 0～4 0万U·kg- 1 ,加入2 5 0 ml生理盐水分2次静脉滴注,两组疗程均为7～14 d。结果 观察组总有效率为96 .35 %。对照组总有效率为78.89%。观察组总有效率明显优于对照组(P<0 .0 5 )。结论 磷霉素钠治疗新生儿RTI疗效确切。

Objective To investigate the effect of sodium fosfomycin in newborns with respiratory tract infection(RTI).Methods The observation group in 219 RTI newborns were treated with sodium fosfomycin 100～300 mg·kg -1 and normal saline 250 ml per day,the control group in180 RTI newborns were treated with penicillin G and normal saline 250 ml for 14 d in two groups.Results The effective rate of the two groups were 96.53% and 78.89% respectively,there was significant difference(P<0.05).Conclusion The effect of sodium fosfomycin on the RTI is reliable.