摘要
眼后节的免疫炎症反应是由多种趋化因子、炎前因子和抗炎因子相互作用的复杂过程。RPE(retinal pigment epithelium)细胞是眼后节细胞因子的主要来源,并在炎症中作为细胞因子的靶目标。通过调节RPE细胞分泌的细胞因子有望调节眼后节的免疫炎症反应,维持视网膜结构功能的完整及内环境的稳定,清除入侵病原体和异体抗原.维持良好的视功能。本文就参与RPE细胞免疫调节的细胞因子和细胞因子对眼后节免疫炎症反应的影响综述如下。
出处
《国外医学（眼科学分册）》
2005年第1期52-56,共5页
Foreign Medical Sciences(Section of Ophthalmology )
基金
福建省重大科学研究基金项目(010A010B)
参考文献21
-
1Enzmann V, Kaufmarm A, Hollborn M, et al. Effective chemokines and cytokines in the rejection of human retinal pigment epithelium (RPE) cell grafts. Transpl Immunol, 1999, 7:9-14.
-
2Nagineni CN, Detrick B, Hooks J J, et al. Toxoplasma gondii infection induces gene expression and secretion of Interleukin 1 ( IL-1 ),IL-6, Granulocyte-Macrophage colony-stimulating factor, and intercellular adhesion molecule 1 by muman retinal pigment epithelial Cells. Infect Immun, 2000, 68: 407-410.
-
3Hoilborn M, Kohen L, Wiedemann P, et al. The influence of proinflammatory cytokines on human retinal pigment epithelium cell receptors. Graefes Arch Clin Exp Ophthalmol, 2001, 239: 294-301.
-
4Holtkamp GM, de Vos AF, Kijlstra A, et al. Expression of multiple forms of IL-1 receptor antagonist (IL-lra) by human retinal pigment epithelial cells: identification of a new IL-1ra exon. Eur J Immunol, 1999, 29: 215-224.
-
5Enzmann V, Faude F, Wiedemann P, et al. The local and systemic secretion of the pro-inflammatory cytokine interleukin-6 after transplantation of retinal pigment epithelium cells in a rabbit model. Curr Eye Re.s, 2000, 21(1):530-534.
-
6Momma Y, Nagineni CN, Chin MS, et al. Differential expression of chemokines by human retinal pigment epithelial cells infected with cytomegalovirus. Invest Ophthalmol Vis Sci, 2003, 44: 2026-2033.
-
7Bian ZM, Elner VM, Yoshida A, et al. Signaling pathways for glycated human serum albumin-induced IL-8 and MCP-1 secretion in human RPE ceils. Invest Ophthalmol Vis Sci, 2001, 42: 1660-1668.
-
8Bian ZM, Elner SG, Yoshida A, et al. Activation of p38, ERK1/2 and NIK pathways is required for IL-lbeta and TNF-alpha-induced chemokine expression in human retinal pigment epithelial cells. Exp Eye Res, 2001 , 73:111-121.
-
9Enzmann V, Hollborn M, Poschinger K, et al. Immunosuppression by IL-10-transfected human retinal pigment epithelial cells in vitro.Curt Eve Res, 2001, 23: 98-105.
-
10Nagalakshmi ML, Murphy E, McClanahan T, et al. Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization. Int Immunopharmacol, 2004, 4: 577-592.
同被引文献29
-
1崔彦,许迅,毕宏生.高糖对牛视网膜微血管内皮细胞和周细胞线粒体活性氧的影响[J].中华眼科杂志,2006,42(2):131-138. 被引量：11
-
2孙广莉,张明昌,程蕾,蒋丽.粉防己碱对大鼠角膜新生血管HIF-1α和VEGF表达的影响[J].眼科新进展,2007,27(2):102-105. 被引量：7
-
3沈玺,谢冰,田洁,徐格致.白细胞介素-2对高糖状态下人视网膜色素上皮细胞的影响[J].中国实用眼科杂志,2007,25(2):237-239. 被引量：1
-
4Schlingemann RO. Role of growth factors and wound healing re-sponse in age-related macular degeneration [ J ]. Graefes Arch Clin Exp Ophthalmol 2004 ;242 ( 1 ) :91-101.
-
5Seaton AD, Sheedlo H J, Turner JE. A primary role for RPE transplants in the inhibition and regression of neovascularization in the RCS Rat[J].Invest Ophthalmol Vis Sci 1994;35(1) :162- 169.
-
6Grimes PA, Laties AM. Early morphological alteration of the pigment epithelium in streptozotocin-induced diabetes:increased surface area of the basal cell membrane[J]. Exp Eye Res 1980; 30(6) :631-639.
-
7Osborne NN, Nash MS, Wood JP. Melatonin counteracts apoptosis in cultured human retinal pigment epithelium cells induced by experimental ischaemia[ J ]. Invest Ophthalmol Vis Sci 1998; 39(12) :2374-2383.
-
8Hu DN, Savage HE, Roberts JE. Uveal melanocytes, ocular pigment epithelium, and Mtiller cells in culture:in vitro toxicology [ J ]. Int Toxicol 2002 ; 21 ( 5 ) :455 -472.
-
9Minchenko A, Bauer T, Salceda S, Caro J. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo [ J]. Lab Invest 1994 ;71 ( 3 ) :374-379.
-
10Hata Y, Clermont A, Yamauchi T, Pierce EA, Suzuma I, Kagokawa H,et al. Retinal expression,regulation,and functional bioactivity of prostacyclin-stimulating factor [ J ]. Clin Invest 2000; 105 (4) :541-550.
引证文献2
-
1徐国兴,李琼,陈瑾,郑学栋,郭健,谢茂松.体外传代培养对人视网膜色素上皮细胞免疫调控能力的影响[J].国际眼科杂志,2008,8(9):1777-1780.
-
2江丹,吴强,宋蓓雯,贾丽丽,杜新华.缺氧和高糖对视网膜色素上皮细胞增生及VEGF、TGF-β1表达的影响[J].眼科新进展,2009,29(4):267-271. 被引量：3
二级引证文献3
-
1燕振国,岳红云,段文娟.高原环境吸氧对兔视网膜脑红蛋白表达的影响[J].眼科新进展,2010,30(7):618-621. 被引量：1
-
2韩小霞,郭长梅,惠延年,王雨生.曲安奈德对高糖培养RPE细胞ICAM-1和ILK表达的影响[J].眼科新进展,2010,30(12):1111-1115. 被引量：1
-
3王静,朱鸿,施彩虹.糖尿病大鼠视网膜中内质网应激蛋白、HIF-1α和血管内皮生长因子的表达[J].国际眼科杂志,2015,15(5):772-776. 被引量：4
-
1郭长梅,王雨生,惠延年,韩泉洪,王静波,马吉献.基质金属蛋白酶在体外视网膜色素上皮细胞损伤模型中的表达[J].国际眼科杂志,2007,7(6):1539-1542. 被引量：1
-
2刘之荣,卞晓红.老龄大鼠慢性脑灌注不足免疫细胞与脑损害[J].中国神经免疫学和神经病学杂志,2001,8(1):12-12.
-
3细胞移植治疗晚期帕金森病效果好[J].河南医学研究,2003,12(2):172-172.
-
4Mechelen,Belgium,石头.寻找GPR3,有的而后放矢[J].中国处方药,2009,8(2):9-9.
-
5李国培,赵刚平,朱敏,黄智,林英杰.翼状胬肉与角膜散光的关系[J].现代医药卫生,2004,20(20):2087-2088.
-
6吴作仲.角膜缘干细胞移植治疗翼状胬肉效果的观察[J].大家健康（学术版）,2013(20):150-150.
-
7张亚丽,王勤美.LASIK对眼后段的影响[J].眼科研究,2006,24(1):103-106. 被引量：4
-
8李漫丽,戚卉,吴雅臻.缺氧、氧化应激对视网膜色素上皮细胞增殖及葡萄糖调节蛋白78表达的影响[J].眼科新进展,2014,34(9):826-829. 被引量：4
-
9侯慧媛,王雨生.血管内皮生长因子诱发脉络膜新生血管的分子机制[J].中华眼底病杂志,2005,21(6):409-412. 被引量：7
-
10张鲲,何守志.bFGF对体外培养牛RPE细胞特异性吞噬功能的影响[J].国际眼科杂志,2006,6(1):72-74. 被引量：3
