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Mylotarg在急性髓细胞白血病治疗中的应用 被引量:1

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摘要 CD33在90%以上的急性髓细胞白血病患者及早期髓细胞表达,为急性髓细胞白血病的治疗提供了理想靶点。目前已用于临床试验的主要有未修饰的HuM195和与同位素偶联的HuM195以及药物偶联的Gemtuzumab Ozogamicin(GO、CMA-676、Mylotarg),其中以Mylotarg最具有应用前景。本文着重对Mylotarg的研究进展作一介绍。
出处 《国外医学(输血及血液学分册)》 2005年第2期140-143,共4页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
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  • 1Kay Grobe,Leland D,Powell LD,et al. Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity. Blood,2002,99(9):3188-3196.
  • 2Jilani I,Estey E,Huh Y,et al.Differences in CD33 intensity between various myeloid neoplasms. Am J Clin Pathol,2002,118(4):560-566.
  • 3Voutsadakis IA. Gemtuzumab Ozogamicin (CMA-676,Mylotarg) for the treatment of CD33+ acute myeloid leukemia. Anticancer Drugs,2002,13(7):685-692.
  • 4Amico D,Barbui AM,Erba E,et al.Differential response of human acute myeloid leukemia cells to gemtuzumab ozogamicin in vitro: role of Chk1 and Chk2 phosphorylation and caspase3. Blood,2003,101(11):4589-4597.
  • 5Matsui H,Takeshita A,Naito K,et al.Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers. Leukemia,2002,16(5):813-819.
  • 6Walter RB,Raden BW,Hong TC,et al. Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells.Blood,2003,102(4):1466-1473.
  • 7Roland B,Brian W,Michelle R,et al. The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin. Blood,2004,103(11): 4276-4284.
  • 8Sievers E,Appelbaum F,Spielberger R,et al.Selective ablation of acute myeloid leukemia usingantibody-targeted chemotherapy: a phaseⅠstudy of an anti-CD33 calicheamicin immunoconjugate. Blood,1999,93(11): 3678-3684.
  • 9Larson RA,Boogaerts M,Estey E ,et al. Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin). Leukemia,2002,16(9):1627-1636.
  • 10Francesco Lo-Coco,Giuseppe C,Massimo B,et al. Gentuzumab ozogamicin(mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia. Blood,2004,10(4):1182-1185.

同被引文献20

  • 1滕有为,郑朝晖,江绍开.环状“烯-二炔”抗癌抗菌素的研究进展[J].合成化学,1994,2(4):295-319. 被引量:6
  • 2杨秀萍.稀有放线菌产生的高效抗肿瘤抗生素[J].微生物学通报,1995,22(1):49-54. 被引量:2
  • 3刘文.烯二炔类抗肿瘤抗生素的生物合成研究进展[J].世界科技研究与发展,2005,27(3):24-31. 被引量:7
  • 4顾觉奋,袁瑞瑛.烯二炔类抗生素的研究新进展[J].药学进展,2005,29(10):433-439. 被引量:5
  • 5Nitin K D,Philip F.Antibody-targeted chemotherapy with immunoconjugates of calicheamicin[J].Pharmacology,2003,3:386.
  • 6Kecke E,Jonas N,Susanne M,et al.Cleavage of cellular DNA by ealicheamicin γ1[J].DNA Repair,2003,2:363.
  • 7Egidio G,Katsunori T,Weidong D,et al.Theoretical simulation of the electronic circular dichroism spectrum of calicheamicin[J].Bioorg Med Chem,2005,13(17):5072.
  • 8Sergio A,Roberto S.Monoclonal antibodies and immunoconjugates in acute myeloid leukemia[J].Best Pract Res Clin Haematol,2006,19(4):715.
  • 9Trail P A,King H D,Dubowchik G M.Monoclonal antibody drug immunoconjugates for targeted treatment of cancer[J].Cancer Immunol Immunother,2003,52:328.
  • 10Chadi N,Lynn M R,Mary B R,et al.Phase Ⅱ pilot trial of gemtuzumab ozogamicin (GO) as first line therapy in acute myeloid leukemia patients age 65 or older[J].Leuk Res,2005,29(1):53.

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