顺铂化疗中肾毒性的监测

Monitoring of toxicity of cis-platinum diaminodichloride to kindeys in chemotherapy

为探讨顺铂化疗中肾毒性的影响，对２４例顺铂治疗的恶性肿瘤患者尿β_２微球蛋白（β_２－ＭＧ）进行监测，并以１０例健康人尿β_２－ＭＧ为正常参考值。结果表明，大剂量组与小剂量组在化疗后同一时间内尿β_２－ＭＧ差异显著（Ｐ＜０．０１）；小剂量Ⅰ组化疗后尿β_２－ＭＧ显著增加（Ｐ＜０．０５）；小剂量Ⅱ组化疗后尿β_２－ＭＧ虽高于正常，但无明显差异（Ｐ＞０．０５）；大剂量Ⅰ组化疗后尿β_２－ＭＧ增加非常显著（Ｐ＜０．０１）；大剂量Ⅱ组化疗后尿β_２－ＭＧ增加，差异非常显著（Ｐ＜０．０１）。提示顺铂小剂量分次给药，大剂量水化及胃复安的应用可明显减低肾毒性。

To investigate the foxic effect of cis- platinum diaminodichloride on kindeys during chemotherapy urine β_2-MG was determined in 24 cancer patients on cis-patinum and in 10 healthy controls. The results showed that there was very significant difference contents in urine β_2-MG between large dosage group and small dosage group in the same time after chemotherapy(P<0. 01). β_2-MG increased in the first group of small dosage (P<0. 05). There was significant difference between the second group of small dosage and the controls (P>0. 05) though the former had a higher level. The first group of large dosage had a marked increase of β_2- MG in urine (P<0. 01). So did the second group of large dosage (P<0. 01). Kindey toxicity could be decreased by using small dosage cis-platinum, large puantity liquid and metoclopranlide.