摘要黑色素瘤抗原-1(melanoma antigen-1，MAGE-1)是由van der Bruggen等于1991年在研究恶性黑色素瘤时发现的人类第一个肿瘤特异性抗原，以后逐渐发现了更多MAGE抗原，现已形成拥有24个结构上相似的基因成员的家族。肿瘤抗原MAGE-3(又名MAGE—A3)是1994年Gaugler等从恶性黑色素瘤中分离出来并进行了鉴定，由两小一大3个外显子(exon)组成，和MAGE-1一样，氨基酸编码序列全部位于第三外显子,
2Van den Eynde BJ,Van der Bruggen P.T cell defined tumor antigens[J].Curr Opin Immunol,1997,9(5):684-693.
3Ge W,Sui YF,Wu DC,et al.MAGE-1/Heat shock protein 70/MAGE-3 fusion protein vaccine in nanoemulsion enhances cellular and humoral immune responses to MAGE-1 or MAGE-3 in vivo[J].Cancer Immunol Immunother,2006,55(7):841-849.
4Marchand M,Weynants P,Rankin E,et al.Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3[J].Int J Cancer,1995,63:883-885.
5Coulie PG,Karanikas V,Colau D,et al.Amonoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3[J].Proc Natl Acad Sci USA,2001,98(18):10290-10295.
6Ma JH,Sui YF,Ye J,et al.Heat shock protein 70/MAGE-3 fusion protein vaccine can enhance cellular and humoral immune responses to MAGE-3 in vivo[J].Cancer Immunol Immunother,2005,54(9):907-914.
7Toso JF,Oei C,Oshidari F,et al.MAGE-1-specific precursor cytotoxic T lymphocytes from a patient with breast cancer:characterization and antigen-specific activation[J].Cancer Res,1996,56:16-20.
