难治性抑郁症患者生命质量的研究

A preliminary study of quality of life in patients with treatment resistant depression

目的 探讨难治性抑郁症患者的生命质量及其与抑郁焦虑症状的关系。方法 采用健康状况调查问卷(SF 36),汉密顿抑郁量表 17项 (HAMD17 )和汉密顿焦虑量表 (HAMA)对 87例难治性抑郁症患者在治疗前和治疗第 4周末分别进行评定。结果 (1)难治性抑郁症患者生命质量中的生理机能与患者年龄呈负相关(r=-0. 37),精神健康与患者的家庭史和本次病程呈显著负相关 (r值分别为 -0. 35和-0. 48)。(2)生命质量总分及因子分与多项HAMD、HAMA总分及因子分呈显著负相关 (P<0. 01 )。(3)治疗后生命质量各维度的提高与HAMD、HAMA总分及焦虑、行为阻滞等因子分的下降呈显著正相关(P<0. 01)。结论 难治性抑郁症患者的生命质量与患者的年龄、文化程度、本次病程及家族史有一定的相关关系,与患者的焦虑抑郁情绪关系密切,随着情绪的改善,患者生命质量也有所提高。

ObjectiveTo explore the refractory depression patients’ quality of life and the relationship between patients’ and the depression 、anxiety symptom. MethodsAssessed 87 refractory depression patients with the Short-Form-36 Health Survey (SF-36)、Hamilton Depression Scale(HAMD 17)and Hamilton Anxiety Scale(HAMA)before treatment and the end of the fourth therapeutic week. Results (1) The refractory depression patients’ quality of life has some correlation with patients’age,educational level,course of disease and family history. (2)The score of is negatively correlated with HAMD and HAMA. (3)The increase of after treatment is significant correlated with the decrease of total score of HAMD,HAMA and some factor score. ConclusionThe refractory depression patients’ quality of life has some correlation with patients’age,educational level,course of disease and family history. Patients’anxiety and depression symptom is also closely correlated with. To improve patients’emotion can enhance the of refractory depression patients.