辅酶B_(12)模型化合物生成与解离电化学研究(Ⅱ)

Studies on the Production and Dissociation of Coenzyme B_(12) Models by Electrochemistry and Spectroelectrochemistry(Ⅱ)

用电化学方法研究了钴卟啉与多种直键溴代烷的相互作用，表明Ⅰ价钴卟啉可以与溴代烷形成有σ钴-碳键的输酶B12模型化合物．计算了Ⅰ价钴卟啉与各种直键溴代烷的加合速率常数．详细讨论了直键烷烃的链长与模型化合物生成速率及烷基钴卟啉负离子稳定性的关系．讨论了几种模型化合物的优劣．

The reaction of CoTPP (cobalt tetrophenylporphyrin) with various alkyl bromides [CH3CH2Br; CH3(CH2)3Br; CH3(CH2)7Br; CH3(CH2)11Br; CH3(CH2)15Br] were studied by cyclic voltanungram.The reaction of [Co(I )TPP]- with alkyl brondde formed coenzym B12 moddel compound containing a cobalt-carbon bond. The formation rate constants are 2.43; 16.73; 28.30; 35.05; 42.36 mol-1·L·s-1 respectively. The relation between the chain length of alkyl bromide the rate constans and the stability of alkyl cobalt porphyrin negtive ion were discussed.