罗汉果甜苷的毒性作用研究

Experiments Studies on the Non-toxicity Action of Mogrosides

目的:研究罗汉果甜苷的毒性作用。方法: 按文献方法用小白鼠进行急性毒性试验,用标准伤寒沙门氏菌做Ames 致突变试验。用家犬进行4周毒性试验。结果:罗汉果甜苷灌胃,对小白鼠的LD50>10000mg/kg,属实际无毒级。Ames 致突变试验结果为阴性。罗汉果甜苷3.0g/kg (相当于人用量的250倍) 灌胃4周,对家犬的血液学指标、肝、肾、功能、血糖与尿糖以及心、肝、肾、肺、脾的形态学变化均无明显的影响。结论:罗汉果甜苷是一种基本无毒的物质。

Objective: To study the toxicity of Mogrosides. Methods: Acute toxicity experiments with mice. Ames test with Salmonella typhosa (TA97, TA98, TA100, TA102), and four weeks toxicity experiment with dogs were administrated according to documents. Results: The LD50 of Mogrosides by i.g. to mice was large than 10000mg/kg .It was actual no toxicity. The Ames result of Mogrosides was also negative .The dogs were given (i.g.) Mogrosides 3.0g/kg for four weeks and the detection and examination results showed that there were no changes in dog’s blood constituents, liver function and kidneys.The dog’s blood and urine sugar level were normal. Mogrosides also made no morphologic changes to heart, liver, kidneys, lungs, and spleen in dogs. Conclusion: Mogrosides was one kind of components without toxicity.