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Na^+/H^+交换器抑制剂研究进展 被引量：4

Progress in Na +/H + exchanger inhibitor research
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摘要 目的　综述最新报道的Na+ /H+ 交换器 (NHE)抑制剂的结构类型及其药理作用 ,为新药研究提供借鉴和指导。方法　通过调研近期国内外文献 ,较全面地介绍了NHE抑制剂研究现状及发展趋势。结果与结论　目前已知有 8个NHE亚型分布于人体的不同组织中 ,在细胞缺血 再灌注发生阶段 ,NHE抑制剂对心脏、脑、肾脏和肝脏产生显著的保护作用 ,是一类有效的细胞缺血 再灌注损伤的治疗药物。 No abstract available
作者 雷林 徐云根 华维一
机构地区 中国药科大学新药研究中心
出处 《中国药学杂志》 EI CAS CSCD 北大核心 2005年第5期324-327,共4页 Chinese Pharmaceutical Journal
关键词 Na^+/H^+交换器抑制剂 阿米洛利 缺血-再灌注
分类号 R972 [医药卫生—药品]
  • 相关文献

参考文献27

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二级参考文献79

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共引文献4

同被引文献48

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  • 4SMITH A J, SMITH E C, XU Y M, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation [ J]. Cancer Res, 2005, 65 ( 3 ) : 1027-1034.
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  • 8LIUGL TAOX.Na^+/H^+ exchanger and heart diseases.中国药学杂志,2005,5(5):324-327.
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  • 10JAVADOV S, RAJAPUROHITAM V, KILIC A, et al. Anti-hypertrophic effect of NHE-I inhibition involves GSK-3β-dependent attenuation of mitochondrial dysfunction [ J ]. J Mol Cell Cardiol, 2009, 46(6) :998-1007.

引证文献4

二级引证文献2

中国药学杂志
2005年 第5期

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