摘要
目的 研究莪术油的大鼠体内药动学。方法 采用高效液相色谱法测定莪术油中标志性成分吉玛酮血浆药物浓度。结果 大鼠尾静脉注射及灌胃给药后莪术油指标性成分吉玛酮药时曲线符合静注和口服的二房室模型 ,静注给药t1/2α,t1/2 β分别为 9 890 ,4 1 5 3min ,灌胃给药Ka为 0 4 79h-1,tmax为 3 2 84h ,cmax为 0 5 0 1μg·mL-1。结论 静注给药后吉玛酮在大鼠体内表现为快速分布和消除 ,口服莪术油吸收较慢。
OBJECTIVE: To study the pharmacokinetics of zedoary oil in rats. METHODS: High-performance liquid chromatography method was used. RESULTS: The pharmacokinetics of germacrone (one index component found in zedoary oil) in rats was investigated and their plasma concentration-time course was fitted well to a two-compartment open model, with the following pharmacokinetic parameters: t1/2α, (9.890) min and t1/2β(41.53) min after injection; Ka (0.479) h-1, tmax(3.284)h, c max (0.501) μg·mL-1 after single oral administration. CONCLUSION: The distribution and elimination of germacrone were rapid after injection in rats. The absorption of germacrone was slow after oral administration of zedoary oil.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2005年第5期380-382,共3页
Chinese Pharmaceutical Journal
