NIDDM肾病尿前列腺素的变化及其意义

FUNCTIONAL SIGNIFICANCE AND CHANGES OF RENAL PROSTAGLANDINS PRODUCTION IN NIDDM PATIENTS WITH DIABETIC NEPHROPATHY

作者探讨了ＮＩＤＤＭ肾病尿ＰＧｓ的来源，变化的机理及意义。结果提示它们主要来自肾脏；肾病早期尿ＴＸＢ２、ＰＧＥ２以及ＰＸＢ２／ＰＧＥ２比值即显著升高，６－酮－ＰＧＦ１ａ无明显变化；ＴＸＢ２升高与肾病恶化有关，可提示肾脏早期受损；ＰＧＥ２升高则属肾病的自身保护反应。这些变化可能与肾小球病损及肾脏血流动力学异常有关。

The source of urinary PGs, the mechanism and significance of urinary PGs changes in NIDDM patients with diabetic nephropathy (DN ) were explored. The results indicated that the urinary PGs were primarily produced by kidneys. For incipient DN, urinary excretion of TXB2 and PGE2,and TXB,IPGE, ratios were significantly augmented,but urinary 6-keto-PGF1a excretion was not different from that of controls. The high production of renal TXB2 was involved in deteriorating of DN,and might reveal the presence of early renal damage. However,the increasedrenal PGE2 synthesis might be a beneficial self-regulation resisting against renal damage.These biochemical alterations are associated with changes in pathomorphism and hemodynamics of glomerulers.