TRH兴奋试验对下丘脑－垂体病的诊断意义

SIGNIFICANCE OF TRH STIMULATING TEST IN THE DIAGNOSTS OF HYPOTHALAMUS-PITUITARY DISEASE

作者对１０例正常人，８２例下丘脑－垂体病，５例神经衰弱患者行ＴＲＨ（促甲状腺激素的释放激素）兴奋试验，放免法同步测定血清ＴＳＨ（促甲状腺激素）、ＰＲＬ（泌乳素）和ＧＨ（生长激素）浓度。结果显示：下丘脑－垂体病的ＴＳＨ对ＴＲＨ的异常反应占６４．６３％，ＰＲＬ对ＴＲＨ的异常反应占６４．５６％；肢端肥大症的ＧＨ对ＴＲＨ的异常反应占７１．４％，且与正常人相比均有统计学意义（Ｐ＜０．０１），还讨论了该试验方法的诊断意义。

Plasma TSH, PRL and GH were measured by radioimmunoassay in TRH stimulating test in 10 normal subjects, 82 patients with hypothalamus-pituitary disease and 5 patients with neurosis.The results showed that the response of TSH to TRH was abnormal in 64. 63% cases, and the response of PRL to TRH was abnormal in 64.56% cases with hypothalamus-pituitary disease.The abnormal response of GH to TRH was 71.4% in patients with acromegaly.As compared with the normal persons, the above abnormal responses have statistical significance (P<0.01). Significance of the test in diagnosis of hypothalamus-pituitary disease is discussed.