1046例围产儿尸检病理分析的临床与优生意义

CLINICAL AND EUGENIC SIGNIFICANCE OF AUTOPSY PATHOLOGIC ANALYSIS OF 1046 PERINATAL NEWBORNS

１９８５年１２月～１９９０年１２月底监测围产儿１５３８８１例，死亡３９５５例，尸检１０４６例，检出畸形５６７例，占５４．２１％，居首位。其次胎儿缺氧、肺炎、颅内出血２６３例（２５．１４％）及妊娠合并症１５４例（１４．７２％）。畸形中检出单纯内脏畸形２２８例（占尸检的２１．８％），以心脏畸形７３例（３２．０２％）最多。体表合并内脏畸形１６８例中以肾畸形５６例（３３．３３％）最多。有５３６例靠尸检证实死亡的原因或检出有关的遗传因素，为进一步产前诊断和优生咨询提供依据。

From December 1985 to December 1990,153881 perinatal newborns were surveyed,of the 3955 cases were dead and 1046 cases underwent autopsy 567 of 1046 autopsies (54.21%)were malformed.Other causes included fetal anoxia,pneumonia,intracranial hemorrhage(25. 14%)(26 3 cases)and 154 cases of complication of pregnancy( 14.72%). 228 of 567 malformed cases (21.8%)were single internal organ deformities. 73of 228 cases (32. 02%)were heart deformities, with the highest ratio. 56 of 168 external and internal organ deformities were complicated by kidney deformities(33.33%). In 45.16%(536 deformities ) the autopsy was the sole means of establishing the cause of death or identifying genetic factors, which provides basis for further prenatal diagnosis and eugenic counsel.