雌二醇和孕酮对山羊子宫雌二醇受体的调节

The Regulation of Endometrial Estradiol Receptor by Estradiol and Progesterone in Goats

将１２只卵巢摘除山羊随机分为４组，用孕酮（Ｐ＿４）和雌二醇（Ｅ＿２）按２×２因子实验进行发情周期的人工模拟，然后测定子宫内膜胞浆中的Ｅ＿２受体（ＲＥ＿２），Ｐ４组、空白组、Ｐ＿４＋Ｅ＿２组和Ｅ＿２组的ＲＥ＿２水平分别为８．９，１８．３，３３．８和６７．９ｆｍｏｌ·ｍｇ￣（－１）．除空白组与Ｐ＿４＋Ｅ＿２组之间ＲＥ＿２水平的差异显著外（Ｐ＜０．０５），其余组之间均为极显著（Ｐ＜０．０１）。结果表明，山羊子宫内膜胞浆ＲＥ＿２水平处于Ｐ＿４和Ｅ＿２的共同调节之中，Ｐ＿４具有极显著的降调节作用，而Ｅ＿２则具有极显著的升调节作用。

A 2×2 factorically-designed experiment was conducted.P_4 and E_2 were usedto imitate estrous cycle in 12 OVX goats divided in 4 groups at random artificially.Andthen,E_2 receptor(RE_2)was determined in the cytoplasma of the endometrium of thesegoats. The concentration of RE_2 was 8.9,18.3,33.8 and 67.9 fmol·mg￣(-1) protein inP_4,the control,P_4+E_2 and E_2 groups respectively. Apart from the significant differencein RE_2 concentration between the control and P_4+E_2 groups(P<0.05),there was an ex-tremely significant difference in RE_2 concentration in all the rest groups(P<0.01).Theresults indicate that RE_2 concentration in the cytoplasma of endometrium of these goatsis in co-extence between P_4 and E_2,and that P_4 has an extremely significant function todecrease regulation while E_2 has an extremely significant function to increase regulation.