二羟基乙二肟毒性实验研究

An Experimental Study of Toxicity of Dihydroxyglyxine

本文报道二羟基乙二肟急性经口毒性,小鼠LD_(50)>8000mg/kg、大鼠LD_(50)>5000mg/kg。蓄积系数为2.9,属低毒有明显蓄积作用的物质。对皮肤及眼结膜无刺激作用。其原形物质及其代谢产物主要经肾排出,引起尿路梗阻性病变及肾盂结石,电镜可见肾小管上皮细胞线粒体肿胀、溶酶体增多增大,并使肾组织SDH酶活性下降。血清中尿素氮增高达9.35mmol/L,表明对肾脏有明显的损害,此外对生殖系统也有一定的毒作用。

This paper reported that dihydroxyglyxine (DHG) was an agent of low toxicity and had distinctly accumulative effect. Its oral LD50 in mice was>8 000mg/kg and LD50 in rat was 5 000mg/kg. The accumulation coefficient was 2.9. It did not produce irritation of the skin and conjunctiva in rabbits. The kidney was the main excretory route of DHG and its metabolites which induced pathological change of urethr-emphraxis and renal pelvis stones. Edema of mitochondria of epithelial cell of renal tubules, increase of lysosome in number and change of shape were found on electro-microscopic examination. DHG also decreased the activity of SDH. Serum urea nitrogen ncreased to 9.35mmol/L. These results showed that the target organ of DHG was kidney. In addition, DHG had also some toxic effect on testis.