男性不育患者睾丸活检形态学观察

Morphological Observation on Testicular Biopsies from Male Infertility Cases

60例男性不育睾丸形态学观察表明,睾丸病变主要表现在4个方面:①精子发生障碍(58例,96.7％),伴曲细精管管径缩小;②生精上皮变性,脱落(7例,11.7％);③曲细精管固有膜增厚、变性(43例,71.7％);④间质组织水肿,成纤维结缔组织增生(8例,13.3％)。在检查的60例中只有少数患者表现单一病变,多数患者为混合病变。其中25例进行血清睾酮放射免疫测定,结果为18.06±5.30nmol/L,与正常对照值19.76±5.20nmol/L比较,差异无显著性意义(P>0.05)。

Morphological observation on testicular biopsies from 60 cases of infertile men showed four categories of principal pathological lesions of testes: (1) disturbance of spermatogenesis associated with decreased diameter of seminiferous tubules (58 cases, 96.7%);(2)degeneration of germinal epithelia, associated with cell exfoliation from seminiferous tubules (7 cases, 11.7%); (3) increased thickness of lamina propria associated with tissue hyalinization(43 cases, 71.7%); and(4)edema or fibrous tissue hyperplasia in the interstitial tissue(8 cases, 13.3%).Among these 60 patients, a few showed pathological lesions of one category but the majority produced mixed lesions. Serum testosterone levels of 25 cases were 18.06±5.30 nmol /L. In comparison with control group values (19.76±5.20 nmol/L), the difference was of no statistical significance (P>0.05).