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心脏中的超极化激活的环核苷酸门控通道 被引量：1

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摘要 If离子流是心脏起搏电流的重要组成部分,超极化激活的环核苷酸门控通道 (hyperpolerization activatedcyclicnucleotid gatedchannels,HCN通道)和野生型If离子通道有相似的分子生物学结构和通道动力学特征。对HCN通道的研究成为从分子水平深入探讨心脏起搏机制的重要内容。目前有关HCN通道的研究已取得了一些进展,但其在心脏起搏中的作用机制仍不清楚。
作者 严钰锋 刘远谋
机构地区 上海第二医科大学生理教研室
出处 《国外医学（生理病理科学与临床分册）》 2005年第1期11-14,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 Ⅰf电流 离子通道 心脏起搏
分类号 R33 [医药卫生—人体生理学]
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参考文献24

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同被引文献20

  • 1林世荣,邓玉莲.超极化激活电流及超极化激活的环核苷酸门控通道[J].福建医药杂志,2005,27(3):154-155. 被引量：1
  • 2涂会引,姜玉秋,刘风雨,邢国刚,石玉顺,李潭,姚磊,韩济生,万有.蛛网膜下腔注射ZD7288对神经病理痛大鼠机械性痛敏的影响[J].中国疼痛医学杂志,2006,12(4):228-233. 被引量：6
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  • 5Tu H, Deng L, Sun Q, et al. Hyperpolarization-activated, cyclic nucleotide-gated cation channels : Roles in the differential electrophysiological properties of rat primary afferent neurons [ J ]. J Neurosci Res,200d,76 (5) :713-722.
  • 6Femandez-Velaseo M ,Goren N,Benito G,et al. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts [ J ]. J Physio1,2003,553 (Pt) :395-405.
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  • 10Nolan MF, Malleret G,Dudman JT,et al. A behavioral role for dendritic integration: HCNI channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons [J]. Cell,2004,119(5) :719-732.

引证文献1

国外医学（生理病理科学与临床分册）
2005年 第1期

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