期刊文献+

细胞因子信号转导抑制分子的研究进展 被引量:8

下载PDF
导出
摘要 SOCS是一类新型的免疫抑制分子,可抑制多种细胞因子、激素和生长因子的生物学作用。生理情况下,SOCS在组织中低水平表达。此外,它也受到转录水平、蛋白合成水平及降解水平的严密调控。SOCS分子主要通过抑制JAK/STAT通路抑制信号转导,从而对细胞因子、激素、生长因子作用的强度和持续时间进行调控。
出处 《国外医学(生理病理科学与临床分册)》 2005年第1期14-17,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
  • 相关文献

参考文献19

  • 1Zhang JG, Metealf D, Rakar S, et al. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo[J]. Proc Natl Acad Sci USA, 2001,98(23) :13261-13265.
  • 2Saito H, Morita T, Fujimoto N, et al. IFN regulatory factor-1-mediated transcriptional activation of mouse STAT inhibitor -1 gene promoter by IFN-gamma [J]. J Immunol, 2000, 164 ( 11 ) : 5833-5843.
  • 3Emanuelli B, Peraldi P, Filloux C, et al. SOCS-3 is an insulin-induced negative regulator of insulin signaling [ J ]. J Biol Chem,2000, 275(21 ) :15985-15991.
  • 4Gregorieff A, Pyronnet S, Sonenberg N, et al. Regulation of SOCS-1 expression by translational repression [ J ]. J Biol Chem, 2000,275 (28) :21596-21604.
  • 5Cornish AL, Chong MM, Davey GM, et al. SOCS-1 regulates signaling in response to IL-2 and other gamma c-dependent cytokines in peripheral T cells [ J ]. J Biol Chem, 2003, 278 ( 25 ) : 22755-22761.
  • 6Nakagawa R, Naka T, Tsutsui H, et al. SOCS-1 participates in negative regulation of LPS responses[J]. Immunity, 21302, 17(5) :677-687.
  • 7Yoshikawa H, Matsubara K, Qian GS, et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity[J]. Nat Genet, 2001 ,28(1 ) :29-35.
  • 8Metcalf D, Mifsud S, Di Rago L, et al. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 ( SOCS-1 ) [ J ]. Proc Natl Acad Sci USA, 2002, 99(2) :943-948.
  • 9He B, You L, Uematsu K, et al. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer[J]. Proc Natl Acad Sci USA, 2003, 100(24) :14133-14138.
  • 10Ilangumaran S,Finan D, La rose J, et al. A positive regulatory rolefor suppressor of eytokine sigualing-1 inIFN-gamma-indueed MHC class Ⅱ expression in tibroblasts[J]. J Immunol, 2002, 169(9) :5010-5020.

同被引文献119

引证文献8

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部