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PLD2介导的信号转导功能及其在疾病发生中的作用 被引量：2

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摘要 磷脂酶D2(phospholipaseD2,PLD2)是一较为年轻的PLD家族成员,它可将磷脂酰胆碱裂解为磷脂酸及胆碱。它在细胞功能的诸多方面,如信号转导、膜组分交换、细胞骨架重排、细胞增殖及分化等过程中均有重要的作用。在病理状态下,PLD2可通过相应功能的变化参与某些疾病(如肿瘤、哮喘)的发生与发展。
作者 邹伟斌 朱玲
机构地区 福建医科大学基础医学院免疫学系
出处 《国外医学（生理病理科学与临床分册）》 2005年第1期28-31,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 福建省科技厅基金(2004Y010)
关键词 磷脂酶D2 第二信使 信号转导
分类号 R346 [医药卫生—基础医学]
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参考文献20

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同被引文献57

  • 1王坚苗,张苏明.短暂性脑缺血发作的新认识[J].国外医学（脑血管疾病分册）,2005,13(2):110-115. 被引量：22
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  • 3Katayama K, Kodaki T, Nagamachi Y, et al. Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver[J]. Biochem J, 1998,329 (Pt 3) :647 652.
  • 4Hammond SM, Jenco JM, Nakashima S, et al. Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4, 5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha [J]. J Biol Chem, 1997, 272 (6): 3860-3868.
  • 5Park SH,Ryu SH,Suh PG,etal. Assignment of human PLD2 to chromosome band 17p13. 1 by fluorescence in situ hybridization[J]. Cytogenet Cell Genet, 1998,82 (3-4) : 225.
  • 6Steed PM, Clark KL, Boyar WC, et al. Characterization ofhuman PLD2 and the analysis of PLD isoform splice variants [J]. Faseb J, 1998,12(13) : 1309-1317.
  • 7Exton JH. Phospholipase D: Enzymology, mechanism of regulation and function[J]. Physiol Rev, 1997,77 : 303-320.
  • 8Kang DW,Park MH, Lee YJ ,et al. Phorhol ester up-regulates phospholipase D1 but not phospholipaseD2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells[J]. J Biol Chem,2008,283(7) ..4094-4104.
  • 9Oshimoto H,Okamura S, Yoshida M, et al. Increased activity and expression of phospholipase D2 in human colorectal cancer[J]. Oneol Res, 2003,14(1 ) : 31-37.
  • 10Yamada Y, Hamajima N, Kato T, et al. Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer[J]. J Mol Med.. Berl, 2003,81 (2) :126-131.

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国外医学（生理病理科学与临床分册）
2005年 第1期

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