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肥大细胞增生症与干细胞因子受体(c-kit)突变的关系 被引量：8

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摘要 肥大细胞增生症是一组多种病理机制的疾病,近年来发现c- kit活化性突变也是肥大细胞增生症的一个重要机制,对肥大细胞的增殖和致瘤性有重要作用。c -kit活化性突变和某些肥大细胞增生症临床类型有关。酪氨酸激酶抑制剂等及影响c- kit表达的因素可能会对有c- kit突变的肥大细胞增生症有治疗作用。
作者 吴贤杰 郑敏
机构地区 浙江大学医学院附属第二医院皮肤科
出处 《国外医学（生理病理科学与临床分册）》 2005年第1期87-90,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 肥大细胞增生症 c-kil突变 临床特征 治疗
分类号 R55 [医药卫生—血液循环系统疾病]
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参考文献30

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  • 2Furitsu T, Tsujimura T, Tono T, et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product[J]. J Clin Invest, 1993, 92(4) : 1736-1744.
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同被引文献50

  • 1赵雪莲,王军,汤有才,王西阁,王伟,孟晓晖,王宏,冯建飞.儿童再生障碍性贫血干细胞因子及受体的表达[J].医药论坛杂志,2005,26(5):14-15. 被引量：1
  • 2汤耀卿.代谢性碱中毒的治疗策略[J].外科理论与实践,2006,11(1):1-3. 被引量：3
  • 3魏兆甫.肠易激综合征及其治疗[J].中国基层医药,2006,13(10):1745-1746. 被引量：8
  • 4陈西勇,阴琳琳.肠易激综合征的诊治新进展[J].社区医学杂志,2007,5(04S):38-39. 被引量：13
  • 5杨云生,周殿元,张万岱,张振书,宋于刚.肠易激综合征回盲部肥大细胞的研究[J].中华内科杂志,1997,36(4):231-233. 被引量：47
  • 6Vliagoftis H, Worobec AS, Metcalfe DD, et al. The protooncogene e-kit and e kit ligand in human disease. Allergy Clin Immu nol. 1997,100 : 435-440.
  • 7Barczyk M,Debek W,Chyczewski L. Mast cells in the gastrointestinal tract. Roczniki Akademii Medycznej w Bialymstoku, 1995,40 : 36-57.
  • 8OSullivan M, Clayton N, greslin NP,et al. Increased mast ceils in the irritable bowel syndrome. Neurogastroemerol Motil, 2000,12 : 449-457.
  • 9Park JH,Rhee PL,Kim HS,et al. Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome. J Gastroenterol HepatoI, 2006, 21 :71-78.
  • 10Talley NJ,Butterfield JH. Mast cell infiltralion and degranulation in colonic mucosa in the irritable bowel syndrome, Am J Gastroenterol, 1996, 91:1675-1676.

引证文献8

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国外医学（生理病理科学与临床分册）
2005年 第1期

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