期刊文献+

胰岛细胞移植治疗糖尿病

下载PDF
导出
摘要 胰岛细胞移植是治疗糖尿病的一个有效方法,但供胰的极度缺乏阻碍了这个方法的应用。因此很多科学家在探索胰岛β细胞的其它来源途径。目前出现的热点途径有成体干细胞和胚胎干细胞,基因工程改造的β细胞,异种胰岛细胞等。尽管这些方法都还需进一步完善,但无疑给 1型和 2型糖尿病的治愈带来了希望。
作者 卢瑾 宋惠萍
出处 《国外医学(生理病理科学与临床分册)》 2005年第1期91-93,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 国家自然科学基金(30200136)
  • 相关文献

参考文献20

  • 1Yang TY, Oh SH, Jeong IK, et al. First human trial of pancreatic islet allo-transplantation in Korea-focus on re-transplantation [ J ].Diabetes Res Clin Pract, 2002, 56(2) : 107-113.
  • 2Bonner-Weir S, Taneja M, Weir GC, et al, In vitro cultivation of human islets from expanded ductal tissue [ J ]. Proc Natl Acad Sci USA, 2000, 97( 14): 7999-8004.
  • 3Lechner A, Leech CA, Abraham EJ, et al. Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter[ J ]. Biochem Biophys Res Commun, 2002, 293(2) : 670-674.
  • 4Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets[J]. Science, 2001,292(5520) : 1389-1394.
  • 5Gao R, Ustinov J, Pulkkinen MA, et al. Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture [ J ]. Diabetes, 2003, 52 ( 8 ) :2007-2015.
  • 6Humphrey RK, Bucay N, Beattie GM, et al. Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas[J]. Diabetes, 2003, 52( 10): 2519-2525.
  • 7Treutelaar MK, Skidmore JM, Dias-Leme CL, et al. Nestin-LineageCells Contribute to the Microvasculature but Not Endocrine Cells of the Islet[J]. Diabetes, 2003, 52( 10): 2503-2512.
  • 8Zulewski H, Abraham EJ, Gerlach MJ, et al. Multipotential nestinpositive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes[J]. Diabetes, 2001, 50(3) : 521-533.
  • 9Horb ME, Shen CN, Tosh D, et al. Experimental conversion of liver to pancreas[J]. Curr Biol, 2003, 13(2) : 105-115.
  • 10Yang L, Li S, Hatch H, et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells[J]. Proc Natl Acad Sci USA, 2002, 99( 12): 8078-8083.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部